… 90% of prostate cancers are dependent on androgen at initial diagnosis, and endocrine
therapy of prostate cancer is directed toward the reduction of serum androgens and inhibition of …

… Androgen deprivation therapy can suppress hormone-naïve prostate cancer, but prostate
cancer changes AR and adapts to survive under castration levels of androgen. These …

… downregulation of androgen levels in the circulation or blockade of the androgen receptor
(AR… and/or nonsteroidal anti-androgens hydroxyflutamide and bicalutamide are considered for …

… survival after androgen ablation and to growth of androgen-independent prostate cancer. …
contribute to AR activity in androgen-independent prostate cancer, including AR amplification, …

… Androgens and androgen receptors (AR) play a pivotal … as androgen insensitivity syndrome
(AIS) and prostate cancer, are associated with alterations in AR functions. Indeed, androgen …

… Gregory CW, Johnson RTJ, Mohler JL, French FS & Wilson EM 2001b Androgen receptor
stabilization in recurrent prostate cancer is associated with hypersensitivity to low androgen. …

… -independent prostate cancer. In this report we show that in 5 of 10 patients with metastatic
androgen-independent prostate cancer, the androgen-receptor genes had point mutations, …

… Prostate cancer (PCa) is the leading diagnosed malignancy in men in … androgens and
the androgen receptor (AR) has been studied extensively in PCa. Plasma levels of androgens …

… We analyzed the frequency and relevance of mutations in the coding region of the androgen
receptor (AR) in genomic DNA extracted from 137 specimens of prostate cancer. The …

… prostatic hyperplasia and prostate cancer (PCa). Androgen action is exerted through the
androgen receptor (AR), a 110-kDa member of the steroid receptor family of transcription factors…