… androgen receptor (AR) is highly expressed in androgen-dependent and recurrent prostate
cancer … to low levels of androgens in model systems of androgen-dependent and recurrent …

… prostate gland are dependent on androgen receptor (AR) expression and function. Androgenic
… important roles in prostate carcinogenesis and in metastatic or androgen-independent (AI…

… that prostate cancers are androgen dependent, androgen ablation … for the treatment of
advanced prostate cancer (CaP). … of the androgen receptor in recurrent prostate cancer. J Biol …

… , androgen ablation therapy directed toward a reduction in serum androgens and the inhibition
of androgen receptor (… However, the patient’s response to androgen ablation therapy is …

… Patients with metastatic disease are treated by androgen deprivation therapy (ADT… prostate
cancer (CRPC) usually established as metastases within bone tissue. The androgen receptor …

… of advanced prostate cancer over the last two decades; however, the disease remains
invariably fatal. Androgens and the androgen receptor (AR) play a critical role in prostate …

Androgen receptor (AR) is a validated drug target for prostate cancer based on its role in
proliferation, survival, and metastases of prostate cancer cells. Unfortunately, despite recent …

… cell growth in man, and prostate cancer is the commonest cancer in men in the UK. We …
sites in human prostate cancer tissues, including castrate-resistant prostate cancer (CRPC). We …

… To determine whether the androgen receptor is critical for proliferation of androgen-refractory
prostate cancer cells, we disrupted the activity of the androgen receptor with an antibody …

… prostate cancer cell lines do not express androgen receptor (AR). This contrasts sharply with
human prostate … Although primary cultures and prostate carcinomas maintained in athymic …