… these, BRCA mutations are the most frequent mutation to occur [… BRCA mutations, genomic
analysis with testing guidelines and the role of PARP inhibitors in therapy for prostate cancer…

… Among DDR defects, BRCA mutations show relevant clinical implications. BRCA mutations
are … of BRCA mutations in prostate cancer, focusing on their prognostic and predictive roles. …

… of prostate cancer is greater among BRCA mutation carriers; namely, 1.35-fold and 2.64-fold
greater in BRCA1 and BRCA2 … In the case of functional loss of BRCA1 and BRCA2 genes, …

… BRCA mutation prevalence in 832 Ashkenazi Jewish men diagnosed with localized prostate
cancer … clinical outcome measures among 26 BRCA mutation carriers and 806 noncarriers. …

… BRCA1 and BRCA2 mutation in colorectal cancer,24 we synthesized extant research on
PCa risks in BRCA mutation … of general BRCA mutation as well as stratified meta-analyses by …

… mutation carriers (12, 13). To better elucidate the impact of deleterious BRCA1 and BRCA2
mutations on prostate cancer risk, … of deleterious BRCA1 and BRCA2 founder mutations in …

… Prostate cancer patients with germline BRCA mutations had worse outcomes than … to be
BRCA mutation carriers or noncarriers were compared. Briefly, 67 BRCA mutation carriers with …

… We will also discuss the implications of these mutations in the management of prostate cancer
… We will also discuss the implications of BRCA mutations in the management of PCa and …

… Our results confirm that BRCA1/2 mutations confer a more aggressive PCa phenotype
with a higher probability of nodal involvement and distant metastasis. BRCA mutations are …

… Among these, BRCA1 and BRCA2 mutations stand out for … cancer, with recent evidence
reporting mutated BRCA genes as a risk factor also for the development of male breast cancer [5]…