Circadian rhythm disruption as a contributor to racial disparities in prostate cancer

SS Dasari, M Archer, NE Mohamed, AK Tewari… - Cancers, 2022 - mdpi.com
… rate due to prostate cancer than White men in the United States. Evidence implicates circadian
rhythm disruption (CRD) as a potential driver of prostate cancer risk and progression. AA …

Circadian rhythm in prostate cancer: time to take notice of the clock

WZ Zhu, QY He, DC Feng, Q Wei… - Asian Journal of …, 2023 - journals.lww.com
… Disruption of the circadian rhythm plays a critical role in tumorigenesis of many kinds of
cancers, including prostate cancer (PCa). Integrating circadian rhythm into PCa research not …

Melatonin resynchronizes dysregulated circadian rhythm circuitry in human prostate cancer cells

B Jung‐Hynes, W Huang, RJ Reiter… - Journal of pineal …, 2010 - Wiley Online Library
cancer and exogenous melatonin exhibits antiproliferative effects against certain cancers. In
… imparts antiproliferative effects in prostate cancer via resynchronization of deregulated core …

Genetic variants in the circadian rhythm pathway as indicators of prostate cancer progression

CC Yu, LC Chen, CY Chiou, YJ Chang, VC Lin… - Cancer cell …, 2019 - Springer
… between the circadian rhythm and cancer, we hypothesized that genetic variants in circadian
pathway genes might have impacts on the prognosis of patients with prostate cancer. To …

Inherited variation in circadian rhythm genes and risks of prostate cancer and three other cancer sites in combined cancer consortia

F Gu, H Zhang, PL Hyland, S Berndt… - … journal of cancer, 2017 - Wiley Online Library
… We found common genetic variations in the circadian rhythm and melatonin pathways
were associated with prostate cancer risk in the population of European descent. These …

[HTML][HTML] Women in cancer thematic review: Circadian rhythmicity and the influence of 'clock'genes on prostate cancer

Z Kiss, PM Ghosh - Endocrine-related cancer, 2016 - erc.bioscientifica.com
… Here, we discuss how the circadian rhythm affects androgen levels and … how the circadian
rhythm affects androgen levels and modulates CaP development and progression. Circadian

Circadian clock genes and risk of fatal prostate cancer

SC Markt, UA Valdimarsdottir, IM Shui… - Cancer Causes & …, 2015 - Springer
… We aimed to assess the role of genetic variation in core circadian rhythm genes with the
risk of fatal prostate cancer and first morning void urinary 6-sulfatoxymelatonin levels. …

Circadian genes and risk of prostate cancer in the prostate cancer prevention trial

LW Chu, C Till, B Yang, CM Tangen… - Molecular …, 2018 - Wiley Online Library
… 8 have all linked circadian rhythm disruptions to increased prostate cancer risk. Although no
… the endogenous circadian rhythm have been proposed.9 The endogenous circadian rhythm

Testing the circadian gene hypothesis in prostate cancer: a population-based case-control study

Y Zhu, RG Stevens, AE Hoffman, LM Fitzgerald… - Cancer research, 2009 - AACR
… reduced risk of prostate cancer (9, 10), which provides additional evidence suggesting a
role for circadian disruption in the etiology of prostate cancer. Circadian rhythms are controlled …

Drug-induced epigenomic plasticity reprograms circadian rhythm regulation to drive prostate cancer toward androgen independence

S Linder, M Hoogstraat, S Stelloo, N Eickhoff… - Cancer discovery, 2022 - AACR
… , and the management of advanced prostate cancer with this acquired resistance remains
a … Therefore, furthering our understanding of how ENZ affects prostate cancer biology may …