… , yet few models incorporate patient lines or tissues after these treatments alone or in
combination. This work aims to review the patient-derived models of human prostate cancer that we …

… and prostate cancer tissue as patient-derived explants (PDE)… by BrdU uptake in a
representative prostate cancer explant. (B) … Ki67 as shown in a representative prostate cancer …

… , patient-derived xenograft and circulating tumour cell eXplant models as well as … to model.
For a comprehensive understanding of prostate cancer, the different preclinical models can …

… a commonly used 3D in vitro model, spheroids, and … model of the C4-2B prostatic carcinoma
cell line that does not contain stromal components with a model of PDE from prostate cancer …

… symptoms of benign prostatic hyperplasia (BPH).1, 2 In 1996 prostate cancer had become
… interactions are most important in the pathogenesis of prostate cancer and BPH. [4] Stromal …

… prostate cancer (PCa) require accurate tumor models relevant to human PCa. There are few
animal models … Both animal models are very expensive and tight regulatory constraints limit …

… model system should be useful in the evaluation of chemical, physical, or biological agents
for treatment or prevention of prostate cancers. … A primary explant model of the prostate might …

… prostate cancer as demonstrated by our 3D-ex vivo explant organ culture model system using
clinical human prostate cancers… data from prostate cancer cell lines and xenograft prostate …

… -derived prostate cancer explant model. … models is increased complexity of analysis. With
over 10 years of experience working with patient-derived explants (PDEs) of prostate cancer, …

… in evaluating animal models of prostate cancer. However, it … -line-based prostate cancer
models remain the primary and, … -1 inhibitors 25 in prostate cancer explants cultured on a gelatin …