… model reproduces the morphologic and functional characteristics of human prostate cancer,
… Although prostate cancer (PCa) is the second leading cause of cancer-related death among …

… neuroendocrine prostate cancer (NEPC) PDX models has been demonstrated, and such
models … We also highlight suitable models for various research purposes, including identifying …

… prostate cancer (CaP) bone metastasis through such models. … and the CaP biomarker,
prostate specific antigen (PSA); all … Hence, it highlights the physiological relevance of this model…

… prostate cancer tissues (not included in the data shown in Table 2) were received. One prostate
… to the increase in activator activity reported in the model used in this study include: (a) an …

… Furthermore, several mouse models for prostate cancer as well as for other types of cancer
… To induce differentiation in three-dimensional cultures, cells grown from explant cultures …

… In particular, subpopulations of basal cells, isolated using cell-surface markers, display bi-potentiality
and self-renewal in explant culture and tissue grafts [10, 11]. Luminal cells were …

… it also has a role in cancer progression. For example, in a mouse model of prostate cancer
MAOA knockout mice had reduced risk of invasive cancer and a reduced population of CSCs […

… The incidence of prostate cancer and benign prostatic … Explants of the human prostate have
been maintained under manifold … organ culture model for nonmalignant human prostate. The …

… However, the validity of extrapolation from animal models … maintenance of human prostate
in explant culture for relatively … human prostate of young adults throughout long-term explant …

… serially transplantable PDXs of prostate cancer is the low take … , since most models of prostate
cancer were established prior … We used explants to screen candidate drugs targeting core …