… of a number of models of prostate cancer. This review presents an historical synopsis of
various genetically engineered mouse (GEMs) lines of prostate cancer, highlighting their …

… genes are functionally relevant for prostate tumorigenesis, and whether such functions …
genetically engineered mouse models (GEMMs) of prostate cancer, focusing on those that model …

… , tumor suppressors, and homeobox genes. The experimental approaches used to generate
these mouse models … been utilized to create genetically engineered mouse models for PCa. …

… and genetically engineered mouse models that mimic the human disease has been crucial
in validating the importance of these genetic pathways in prostate cancer. These models …

… cancer stem cells, and tumor plasticity in prostate cancer, … studies of genetically engineered
mouse models (GEMMs). … tumor heterogeneity using mouse models of prostate cancer. …

… This review focuses on transgenic mouse models for elucidating the molecular and cellular
processes that lead to prostate cancer initiation, progression and metastasis, and on their …

… NOTE: Summary of the prostate cancer phenotype of the mouse models used in this study.
The numbers of mice analyzed are indicated; the age refers to the time following tumor …

… the advent of genetically engineered mouse (GEM) models, we now have models of prostate
cancer that are dependent on molecular mechanisms already implicated in human prostate …

… are needed to understand the etiology of prostate cancer and to develop … in mouse genetic
engineering technology has led to generation of a series of mouse models for prostate cancer …

… , our understanding of cellular pathways continues to be built on generations of selectively
bred and genetically modified animals with specific overexpressed or deleted features. …