[177Lu]Lu-PSMA-617 (PluvictoTM): The First FDA-Approved Radiotherapeutical for Treatment of Prostate Cancer

U Hennrich, M Eder - Pharmaceuticals, 2022 - mdpi.com
… After binding to the PSMA receptor, [ 177 Lu]Lu-PSMA-617 is internalized into the PSMA
The suitability of [ 177 Lu]Lu-PSMA-617 for the treatment of prostate cancer patients was …

[177Lu]-PSMA-617 radionuclide treatment in patients with metastatic castration-resistant prostate cancer (LuPSMA trial): a single-centre, single-arm, phase 2 study

MS Hofman, J Violet, RJ Hicks, J Ferdinandus… - The Lancet …, 2018 - thelancet.com
… treatment with [ 177 Lu]-PSMA-617 has high response rates, low toxic effects, and reduction
of pain in men with metastatic castration-resistant prostate cancer who have progressed …

Third-line treatment and 177Lu-PSMA radioligand therapy of metastatic castration-resistant prostate cancer: a systematic review

FE von Eyben, G Roviello, T Kiljunen… - European journal of …, 2018 - Springer
… efficacy of 177 Lu prostate specific membrane antigen (PSMA) radioligand therapy (… prostate
cancer (mCRPC). The aim of our systematic review was to elucidate whether 177 Lu-PSMA

177Lu-PSMA-617 radioligand therapy and outcome in patients with metastasized castration-resistant prostate cancer

A Bräuer, LS Grubert, W Roll, AJ Schrader… - European journal of …, 2017 - Springer
prostate-specific membrane antigen (PSMA) have been established for the treatment of
metastasized castration-resistant prostate cancer (… patients treated with 177 Lu-PSMA-617. …

[HTML][HTML] Analysis of PSMA expression and outcome in patients with advanced prostate cancer receiving 177Lu-PSMA-617 radioligand therapy

R Seifert, K Seitzer, K Herrmann, K Kessel… - Theranostics, 2020 - ncbi.nlm.nih.gov
… castration-resistant prostate cancer (mCRPC) 1 . However, the treatment of mCRPC
patients with 177 Lu-PSMA-617 (Lu-PSMA) achieves biochemical response (> 50% decline of …

PSMA PET total tumor volume predicts outcome of patients with advanced prostate cancer receiving [177Lu]Lu-PSMA-617 radioligand therapy in a bicentric analysis

R Seifert, K Kessel, K Schlack, M Weber… - European Journal of …, 2021 - Springer
… end-stage prostate cancer receiving Lu-PSMA therapy [12, 15]. In line with the concept of
theranostics, high SUV mean is associated with higher tumor doses of Lu-PSMA therapy and …

… with metastatic castration-resistant prostate cancer with low prostate-specific membrane antigen (PSMA) expression deemed ineligible for 177Lu-labelled PSMA …

SP Thang, J Violet, S Sandhu, A Iravani… - European urology …, 2019 - Elsevier
Prostate-specific membrane antigen (PSMA) is overexpressed in metastatic castration-resistant
prostate cancer (… trial of 177 Lu-PSMA-617 radioligand therapy in men with high PSMA

177Lu-PSMA radioligand therapy for prostate cancer

WP Fendler, K Rahbar, K Herrmann… - Journal of Nuclear …, 2017 - Soc Nuclear Med
Lu-PSMA RLT targets PSMA, which is expressed at high levels on the surface of prostate
cancer cells (4). PSMA expression remains high in metastases even after multiple lines of …

177 Lu-PSMA-617 radioligand therapy of metastatic castration-resistant prostate cancer: Initial 254-patient results from a prospective registry (REALITY Study)

F Khreish, Z Ghazal, RJ Marlowe, F Rosar… - European Journal of …, 2022 - Springer
… , and safety associated with 177 Lu-PSMA-617 RLT in a … control by 177 Lu-PSMA-617 RLT,
as reflected by prostate-specific … biochemical disease control by 177 Lu-PSMA-617 RLT was …

[177Lu] Lu-PSMA-617 versus cabazitaxel in patients with metastatic castration-resistant prostate cancer (TheraP): a randomised, open-label, phase 2 trial

MS Hofman, L Emmett, S Sandhu, A Iravani… - The Lancet, 2021 - thelancet.com
… with metastatic castration-resistant prostate cancer. We aimed to compare [ 177 Lu]Lu-PSMA-617
with cabazitaxel in patients with metastatic castration-resistant prostate cancer. …