… the mechanisms of resistance that cause hormone-naive prostate cancer to progress to
castration-resistance … knowledge regarding the mechanisms leading to castration resistance, the …

… Instead of revisiting each of these mechanisms, this section will highlight findings on
resistance to therapies administered for CRPC. Representative mechanisms are summarized in …

… on mechanisms that become dysregulated as prostate cancer patients develop resistance
to … Developmental strategies showing promise for overcoming acquired resistance will be …

… Keywords for the search were castrate resistant prostate cancer, abiraterone, enzalutamide
resistance mechanisms, resistance to androgen deprivation, AR mutations, amplifications, …

… The complex mechanism of hormone resistance has … resistance in prostate cancer. Research
data show many different processes to be involved in the acquisition of hormone resistance…

… issues of primary and acquired resistance. This review focuses on mechanisms of resistance
to AR-… with primary resistance, or eventually acquire resistance when on treatment. Multiple …

… mechanisms involved in the development and progression of castration-resistant prostate
cancer is paramount to the development of targeted agents to overcome these mechanisms. A …

… targets and possible cross-resistances of prostate tumours to other treatments. In this …
reported mechanisms of enzalutamide resistance in preclinical models of prostate cancer …

… to review the mechanisms of prostate cancer resistance, … of disease (Castration-Resistant
Prostate Cancer—CRPC) which … This paper aims to address the mechanisms of resistance in …

… the primary driver of castration-resistant prostate cancer (CRPC) have led … prostate cancer
but are not curative. In this Review, we highlight emerging mechanisms of acquired resistance …