… of prostate cancer progression. In this review we summarize the properties of the prostate
cancer model systems … This review will guide the investigator seeking models with which to test …

… -cancerous cells but can become deranged in cancer settings. An important consideration
to make using DU-145 cells as an in vitro model system is the presence of the pro-apoptotic …

… However, from a Three Rs perspective, alternative models should be considered to replace
… models for use within the context of prostate cancer research, including mathematical models…

… Each model system displays its own characteristics regarding androgen responsiveness …
appropriate model system for a particular question. This review summarizes in vitro cell models …

… Cryosurgery offers a promising therapeutic alternative for the treatment of prostate cancer. …
these variables in an in vitro prostate cancer model. Human prostate cancer PC-3 and LNCaP …

… When considering appropriate model systems to study human prostate cancer, one must
acknowledge crucial disease-specific attributes. These include, but are not limited to (1) the …

… of human prostate cancer complicates the development of relevant model systems that mimic
… genetic changes have been associated with prostate cancer that appear to correlate with …

… Prostate cancer (PC) model systems that reflect the different disease stages are essential for
… progression model and compares it to other available human PC cell lines and xenografts. …

… the prostate showing an outlined small area of prostate cancer within the grey rectangle and
an area containing high-grade prostatic … core illustrates prostate cancer comprising Gleason …

… in vitro models for prostate cancer, with particular emphasis on 3D systems and the challenges
that remain before their potential to advance our understanding of prostate disease and …