… Here, we present evidence, by using different in vitro and in vivo prostate cancer models,
that edelfosine exerts a significant antitumor activity against prostate cancer, promoting …

… with low lytic properties support the use of edelfosine as a putative clinical drug [30]. Edelfosine
affects several biophysical parameters on model lipid membranes, similarly to a number …

… activity of edelfosine was found in preclinical models, in both … The only clinical application
of edelfosine at this moment is … of breast, ovarian and prostate cancer models, associated with …

… Edelfosine shows a high affinity for both model and cell … lipid edelfosine is its selectivity in
inducing apoptosis in cancer cells, … to the preferential drug uptake by cancer cells by a not yet …

… rodent and human cancer and cancer stem cell models as well as … Influence on its enzymatic
activity was exerted by edelfosine, … -mutant PC-3 prostate cancer cells were sensitive to peri…

… has demonstrated in vivo efficacy in tumor models in both … a single agent on recurrent prostate
cancer, adenocarcinomas, … While, in A431 cells, micromolar doses of edelfosine inhibited …

… alkylphospholipid analogs (APLs), such as edelfosine… prostate carcinoma xenograft model,
where the combination of perifosine and radiation had a significantly stronger effect on tumor …

… the selectivity of the antitumor lipids for cancer cells follows. An updated model on the mode
of action of … While injection of edelfosine alone was surface active, injections of edelfosine in …

… erucylphosphocholine to combat prostate cancer has been studied … to the monolayer mimicking
prostate cancer membrane (… were found to fluidize the model membrane, which may lead …

… : alkyl-lysophospholipids and alkylphospholipids (1). Edelfosine was initially considered a
very … in vitro and in vivo (in murine models) and was proven to be effective (6, 9, 10). However, …