… Nevertheless in human metastatic lesions, and late-stage carcinomas and metastatic deposits
from a murine model of prostate cancer, JNK phosphorylated forms seem to be reduced […

… We generated a mouse model of prostate cancer progression using … tyrosine kinase activity
is evident in prostate cancer models that do not express mutated or amplified tyrosine kinases…

… To determine whether the pattern of Aurora kinase expression in mouse prostate cancer
models paralleled those in clinical samples, we examined four TRAMP mouse …

… Because EphA2 is overexpressed in metastasis-derived canine prostate cancer cells, the
canine prostate cancer model could be utilized to test EphA2-specific strategies designed to …

… in prostate cancer cell and mouse models correlated with the … A key regulator of this balance
is sphingosine kinase-1 (… inhibition strongly sensitized prostate cancer cells to the effects …

… prostate cancer growth and/or metastasis. In this study, we used the small molecule SFK/Abl
kinase … and in vivo effects of inhibiting SFKs in prostate tumor cells. In vitro, dasatinib inhibits …

… the initial appearance of prostate cancer phenotypes and the … of PI3-kinase and Ras signaling
promotes prostate cancer … metastatic prostate cancer in response to Ras and PI3-kinase …

… prostate cancer cells, we propose that these enzymes are potential therapeutic targets in
prostate cancer. … levels in multiple cellular models of prostate cancer, we next determined if its …

… some outstanding challenges related to kinase-targeted therapy for prostate cancer. For
example, a KI is yet to be approved for the treatment of prostate cancer, as monotherapy or in …

… of prostate cancer in a mouse xenograft model [76]. These studies, together with others,
provide a strong clinical rationale for targeting the PI-3 kinase p110β for prostate cancer …