… develop from hormone-sensitive prostate cancer (HSPC) to castration-resistant prostate
cancer (CRPC). The main reason is PC heterogeneity and evolution during therapy. PC …

… In this review, we summarise how prostate cancer cells evade androgen deprivation therapy
and become more aggressive. Defining the molecular mechanisms will be critical for the …

… Our integrative analysis identified four molecular … molecular co-occurrence and risk-based
subgroup information to deconvolve the molecular and clinical trajectories of prostate cancer …

… prostate cancer and is divided into three parts. The first discusses the cellular origins of
prostate cancer, the second; prostate cancer's … the specific molecular defects of the cancer. …

… At present this event defines the main molecular subtype of prostate cancer. Point mutations
are believed to be less contributory in prostate carcinogenesis, with exome sequencing …

… The analysis of mutational spectrum of GP3 and GP4 tumors allowed defining the time of
occurrence of their molecular evolution. Thus, VanderWeele and coworkers examined, by …

… We review the biology of advanced prostate cancer, and highlight opportunities and challenges
for using biological or molecular assays to help guide individualized treatment decisions …

… Given the importance of structural genomic alterations in prostate cancer genesis and … of
57 prostate cancers to define a spectrum of oncogenic events that may operate during prostate …

… To characterize the subclonal architecture of androgen-deprived metastatic prostate
cancer, we performed whole-genome sequencing (WGS) of 51 tumours from 10 patients to an …

… In this paper, we use methods from molecular evolutionary genetics designed to test for
the signal of diversifying selection across species in a phylogenetic context. We use these …