Accumulating evidence has shown that tauroursodeoxycholic acid (TUDCA) is
neuroprotective in different animal models of neurological diseases. However, whether
TGR5 agonist TUDCA can improve lipopolysaccharide (LPS)-induced cognitive impairment
in mice is less clear. Using a model of cognitive impairment with LPS (2.0 μg) we
investigated the effects of TUDCA (200 or 400 μg) on cognitive dysfunction and neurotoxicity
in mice. Both Morris water maze and Y-maze avoidance tests showed that TUDCA treatment …

Purpose: Animal and cell culture models of human retinitis pigmentosa (RP) suggest that
apoptosis underlie part of the etiology of this disease family. Tauroursodeoxycholic acid
(TUDCA) is an endogenous bile acid that reduces neuronal cytotoxicity in animal models of
Huntington's disease and in drug-induced neuronal apoptosis both in cell culture and in
vivo. The goal of the project was to investigate whether TUDCA inhibits apoptosis in human
retinoblastoma cells undergoing oxidative damage. Tert-butyl hydroperoxide (tBH), a …