… To further examine whether mitochondria function in skeletal muscle fibers is impaired
without CHCHD10, we checked the ATP levels in Ad-Ctrl and Ad-Cre infected CHCHD10 f/f …

… enriched at cristae junctions but the role played by this protein in both … Here, we show that
CHCHD10 is a component of the … The protein levels of assembled CHCHD10 and CHCHD3 …

… mutant versions of CHCHD10, but not WT, have impaired mitochondrial energy metabolism.
… However, ATD3A, a single-transmembrane IM protein located in the ER-mito junctions was …

… proteins can lead to mitochondrial impairment and cell demise, which are associated with
a range of human disorders … CHCHD10 is located in IMS and enriched at crista junctions. …

… CHCHD10 from the other twin CX9C family members is the causal association of several
mutations in both proteins with a myriad of neurodegenerative disorders, in particular ALS for …

… , which is found near the mitochondrial cristae junction, was reported to be resident in the …
aggregates in mitochondria, it causes mitochondrial dysfunction and activation of the PINK1-…

… dysfunction can trigger motor neuron degeneration, through identification of CHCHD10
encoding a mitochondrial protein… mitochondrial dysfunction associated with CHCHD10 mutations …

… We show that nuclear CHCHD10 protein down-regulates the expression of genes harboring
… CXXC finger protein 5 (CXXC5). We further show that two genetic CHCHD10 disease …

… CHCHD2 and/or CHCHD10 binding to various target proteins (such as OPA… impairments
and motor neuron diseases. This review focuses on the functions of CHCHD2 and/or CHCHD10…

… these disorders is revealing how mitochondrial dysfunction … , driven by protein misfolding
of CHCHD2 and CHCHD10 into … and CHCHD10 transiently interact with cristae junction …