… Adduct determination indicates the amount of genotoxic material that has reached … Protein
adducts are not repaired and are considered simply as exposure monitors, but DNA adducts …

… acid excretion and DNA and protein adduct concentrations. This … of mercapturic acids, protein
and DNA adducts, and other … , similar to protein and DNA adducts, mercapturic acids might …

… DNA adducts were predominant in terms of relative quantity and prevalence in different cell
types, we may conclude that oxidative DNA damage is the predominant type of DNA damage …

… electrophiles can then result in the formation of GSH, protein, and DNA adducts ( … -mediated
DNA damage. Unfortunately, to date, the analysis of urinary DNA adducts of lipid …

… tightly to cisplatin adducts than to oxaliplatin adducts [19], [… proteins to cisplatin–DNA
adducts has been postulated to inhibit nucleotide excision repair [21], [22] and/or translesion DNA …

… of the utility of using purified bacterial DNA repair proteins to detect specific DNA lesions,
eg, 8… III and the use of the UvrABC excinuclease protein complex which can detect bulky wx …

… with DNA to form DNA adducts. The same electrophilic species also react with cellular proteins…
of elevated levels of carcinogen–DNA adducts in many human tissues and of carcinogen–…

… of RCS generation, protein/DNA adduct formation, and their … roles of RCS-induced protein/DNA
modifications in signaling … enzymes, RCS-modified protein/DNA adducts, and signaling …

… arsenite-induced DNA damage. We conclude that arsenite induces DNA adducts through
calcium-mediated production of peroxynitrite, hypochlorous acid, and hydroxyl radicals. …

… AMS has demonstrated great value in identifying chemicals that bind covalently to DNA or
protein and quantifying adducts in humans and animal models. Using AMS, elevated levels of …