… Once Src is activated, the Src-induced activation of Ras employs many … growth factor
receptors with intrinsic tyrosine kinase activity. After activation of Pyk2 and Src, the adaptor protein …

… The EGF receptor protein itself possesses protein kinase activity with specificity for tyrosine
residues in substrate proteins (14). This tyrosine protein kinase activity is reduced after phos…

… factor glycogen synthase kinase 3 insulin-like growth factor mitogen activated protein MAP
kinase kinase nerve growth factor platelet-derived growth factor PIP3-dependent kinase 1 6-…

… growth factor (NGF… activity of two protein kinases by >20-fold within minutes8, both strikingly
similar to MAPKs. They are inactivated by either protein-tyrosine phosphatases or the protein…

… An emerging body of evidence implicates the mitogen-activated protein kinase (MAPK) as …
of the mitogen-activated protein kinase (MAPK) pathways in TGF-β1 signaling32., 33., 34., 35.. …

… to inhibitors of tyrosine protein kinases, require p21 ras activation, and are independent
of protein kinase C. These data suggest that some tyrosine kinase growth factor receptors (eg …

… kinase activation blocks differentiation but has little effect on proliferation. In contrast, while
p38 mitogen-activated protein kinase is activated … and sustained activation of this kinase is …

… kinase C in the mechanism of activation by these growth factors demonstrated that specific
inhibition of protein kinase … -3 induced stimulation of MAP kinase activity. The use of synthetic …

… Jun-NH2-terminal kinase activation mediated by UV-induced DNA … p38 mitogen-activated
protein kinase through the … kinase and p38 mitogen-activated protein kinase activation. J…

… activation of Ras or its downstream effectors such as mitogen-activated protein kinase kinase
… However, in melanoma, activating mutations in Ras are rarely observed and are limited to …