… involvement of protein kinase C, but not protein kinase A, in the antinociception caused by …
overt nociception by intraplantar PMA injection (a protein kinase C activator). Another piece of …

… The purpose of the present study was therefore to evaluate the peripheral, spinal, and
supraspinal antinociceptive effects and some of the mechanisms underlying the action of the …

… The thermal antinociception was prevented by naloxone and by the protein kinase C (PKC)
activator PMA, whereas the chemical antinociception was prevented by PMA, remaining …

… to investigate the effects of a highly selective protein kinase C … antinociception. In conclusion,
concomitant it injection of a specific protein kinase C inhibitor, but not of a protein kinase …

… -mediated response, account for the antinociceptive action of dipyrone in mice. Furthermore,
… the protein kinase C-dependent pathway plays a role in the dipyrone antinociceptive action. …

… sum of all of the selective inhibitory effects, demonstrating that the blockade of both COX
isoforms is more efficacious in the production of antinociception. Moreover, sympathetic fibre-…

… Furthermore, stressing that the antinociceptive effect of dipyrone is after generation of cAMP,
we showed that the dose-dependent increase of mechanical hypernociception induced by …

… protein kinase (p38 MAPK) in the spinal cord in the development of chronic morphine
antinociceptive … in the development of morphine antinociceptive tolerance. Inhibition of p38 MAPK …

… The present study investigated the antinociceptive effect of p-… This compound given by oral
route (po) produced antinociception … (MeOPhSe) 2 showed an antinociceptive effect when …

… of PKCγ in the early opioid antinociceptive effects and in the delayed pronociceptive … the
early antinociceptive effect of opioids was followed by a delayed hyperalgesic effect for several …