A role for mitogen‐activated protein kinases in the etiology of diabetic neuropathy

T Purves, A Middlemas, S Agthong, EB Jude… - The FASEB …, 2001 - Wiley Online Library
… that activation of these kinases contribute to the onset of diabetic neuropathy. We propose that
… basis of a preventative treatment for diabetic neuropathy and other diabetic complications. …

Methylcobalamin effects on diabetic neuropathy and nerve protein kinase C in rats

H Mizukami, S Ogasawara… - European journal of …, 2011 - Wiley Online Library
… , however, how MC influences on peripheral nerve in experimental diabetic neuropathy. …
activities of protein kinase C (PKC) in peripheral nerve of streptozotocin-induced diabetic rats. …

Protein kinase C and the development of diabetic vascular complications

KJ Way, N Katai, GL King - Diabetic Medicine, 2001 - Wiley Online Library
… C4, also present in the C-terminal, contains the protein kinase … to the development of
diabetic neuropathy, as vasodilator … The role of PKC in contributing to diabetic neuropathy still …

Roles of Neuronal Protein Kinase Cε on Endoplasmic Reticulum Stress and Autophagic Formation in Diabetic Neuropathy

YY Kan, YS Chang, WC Liao, TN Chao… - Molecular …, 2024 - Springer
diabetes often experience chronic diabetic neuropathy (DN), which presents as sensory
neuropathy … results in chronic pain through the activation of protein kinase C epsilon (PKCε) [2, 3]…

Update on the pathogenesis of diabetic neuropathy

IG Obrosova - Current diabetes reports, 2003 - Springer
… -oxidation, activation of protein kinase C, enhanced oxidative stress… protein kinases and
poly (ADP-ribose) polymerase that are activated by diabetes, and contribute to such neuropathic

The role of protein kinase C activation and the vascular complications of diabetes

ND Evcimen, GL King - Pharmacological research, 2007 - Elsevier
… Hyperglycemia-induced iscemia has also been suggested to play a role in the development
of diabetic neuropathy, since vasodilators, which increase nerve blood flow, appear to …

Mitogen-activated protein kinase p38 mediates reduced nerve conduction velocity in experimental diabetic neuropathy: interactions with aldose reductase

SA Price, S Agthong, AB Middlemas, DR Tomlinson - Diabetes, 2004 - Am Diabetes Assoc
… This study examined the role of p38 mitogen-activated protein (MAP) kinase in … of diabetic
neuropathy. p38 activation and NCV were measured in streptozocin-induced diabetic rats …

Enhanced activation of axonally transported stress‐activated protein kinases in peripheral nerve in diabetic neuropathy is prevented by neurotrophin‐3

A Middlemas, JD Delcroix, NM Sayers, DR Tomlinson… - Brain, 2003 - academic.oup.com
The objective was to determine whether stress‐activated protein kinases (SAPKs) mediated
the transfer of diabetes‐induced stress signals from the periphery to somata of sensory …

Activation of protein kinase C isoforms and its impact on diabetic complications

P Geraldes, GL King - Circulation research, 2010 - Am Heart Assoc
… The contribution of PKC activation to diabetic neuropathy still requires clarification. PKC
contributes to diabetic neuropathy by a neurovascular mechanism such as blood flow and …

… δ-opioid receptor activation reduces neuronal voltage-gated sodium channel (NaV1. 7) levels through activation of protein kinase C in painful diabetic neuropathy

M Chattopadhyay, M Mata, DJ Fink - Journal of Neuroscience, 2008 - Soc Neuroscience
diabetic neuropathy an increase in p-PKC and p-p38 correlated with the increase in amount
of the TTX-sensitive Na V isoform Na V 1.7 in DRG neurons in rats after 6 weeks of diabetes, …