… kinase‐induced mRNA stabilization. Recently stabilization of IL‐6 and cyclo‐oxygenase
mRNAs … of ∼1 μM, which selectively inhibit p38 MAP kinase (Miyazawa et al., 1998; Ridley et al.…

… The mitogen-activated protein kinase (MAPK) cascade is one of the most important intracellular
signaling pathways that plays a crucial role in cell proliferation, cell differentiation and …

… )triphosphate–induced nucleocytoplasmic shuttling of the mRNA stabilizing factor HuR in
human (h) mesangial cells (MC). Using synthetic protein kinase C (PKC) inhibitors and small …

… The present study, using a tetracycline chase procedure, provides proof of p38-dependent
Cox-2 mRNA stabilization, operating through the p38 substrate MAPKAPK-2, and possibly …

… The fact that mRNA stabilization by the p38/MK2 kinase cascade and that by HuR require …
suggests that the two modes of stabilization can operate in different physiological situations. …

… proteins binding to these RNA sequences (ARE uPA/uPAR ) are not known. We show here
that the mRNA-stabilizing … of mitogen-activated protein kinase-activated protein kinase 2 (MK2…

… induces p21 Cip1 mRNA stabilization, without affecting its transcription or the stability of the
protein. In particular, p38 MAPK phosphorylates the mRNA binding protein HuR on Thr118, …

… on 13 independent cell treatments and array hybridizations, and furthermore we have
submitted half-lives for 425 AU-rich mRNAs that did not show stabilization by p38 in this study. …

… To address the question of whether NF90 is also involved in PMA-induced IL-2 mRNA
stabilization, we transfected Jurkat cells with control siRNA and/or NF90 siRNA. Forty-eight hours …

… for the stabilization of TTP mRNA, and phosphorylation by MK2 leads to increased TTP
protein stability but reduced ARE affinity. These data suggest that MK2 inhibits the mRNA …