… , involving diverse protein kinase families. … protein kinase II, mitogen-activated protein
kinase (MAPK) family members c-Jun N-terminal kinase and extracellular signal-regulated kinase …

… A major event that is central to neuronal injury during and after ischemic stroke is the
release of the excitatory neurotransmitter, glutamate. Glutamate acts postsynaptically at several …

… Protein kinase cascades in CNS injury and repair. Hypothetical sequence of events leading
from … signaling after trauma in astrocytes and other neural cells. Other factors in addition to …

… by endogenous mechanisms when neurons were under ischemic … kinase protein kinase
D (PKD) as the primary kinase … death signaling and neuroprotection against ischemic injury. …

… injury in the adult (surviving neurons), whereas its activity was downregulated in injured
neonate motoneurons (dying neurons)… of Akt activation in response to nerve injury for survival. In …

… Because cAMP can interact with targets other than protein kinase A, we also examined
the effect of the membrane-permeable protein kinase A inhibitor H89 on the reversal of …

… As to the mechanism, we have reported recently that zinc-induced neuronal death … protein
kinase C (PKC) in neurons is likely to play a key role in zinc-induced oxidative neuronal injury. …

… protein kinases (ERK), c-Jun N-terminal kinases and p38 MAPK, have been implicated in
neuronal injury and … The MAPK signaling module is defined by a three-tiered kinase cascade, …

… (ERK) 1/2 and p38 are rapidly phosphorylated after mechanical trauma injury in neuron and
astrocyte cocultures. Total (phosphorylated and nonphosphorylated) levels of ERK 1/2 and …

… In summary, replacement of dead neurons in an injured CNS region requires the modification
of the extracellular environment to generate a neurogenic niche in which the progeny of …