… by a cascade of protein kinases. In the mitogen-activated protein kinase pathway, the cascade
… Kinases structurally analogous to MEK in the SAPK pathway are SEK1 and MKK7; in the …

… One of the closest sequence matches to these in humans was the protein kinase LKB1, and
compelling evidence now indicates that this is the key upstream kinase in mammalian cells (…

Nearly all cell surface receptors utilize one or more of the mitogen-activated protein kinase
cascades in their repertoire of signal transduction mechanisms. Recent advances in the study …

… characterized subfamilies of mitogen-activated protein kinases (MAPKs) that control … protein
kinases phosphorylate and activate one another. The extracellular signal–regulated kinases …

… Both MAP kinases and the protein kinase ~74”“’ are activated … protein kinase is upstream
of MAP kinases and is either a MAP kinase kinase kinase or a MAP kinase kinase kinase kinase…

… mediated by protein kinase C (… kinase/mitogen-activated protein kinase (ERK/MAPK)
cascade. It is shown that dominant-negative PKC-α inhibits stimulation of the ERK/MAPK pathway …

… through the interplay of multiple signaling pathways. Among these are the highly conserved
mitogen-activated protein kinase (MAPK) pathways, which are the central mediators that …

… MAP kinase pathways … pathway that controls the last of these processes, mediated by the
single yeast homologue of mammalian protein kinase C and its connections to other pathways (…

… maydis may affect the MAPK and the cAMP-protein kinase A (PKA) pathway, respectively.
A potential activator of Ras2 is the Cdc25-like guanine exchange factor protein Sql2 (104). …

… pathway, namely phosphoinositide-dependent kinase-1, protein kinase B and glycogen
synthase kinase-3, including insights into their mechanisms of regulation, substrate proteins and …