The prolyl oligopeptidase family
L Polgar - Cellular and Molecular Life Sciences CMLS, 2002 - Springer
… Several complementary DNAs (cDNAs) related to the proteins of the prolyl oligopeptidase
… and the antimanic drug valproate restore prolyl oligopeptidase activity to normal levels [30]. …
… and the antimanic drug valproate restore prolyl oligopeptidase activity to normal levels [30]. …
On the role of prolyl oligopeptidase in health and disease
JA García-Horsman, PT Männistö, JI Venäläinen - Neuropeptides, 2007 - Elsevier
… Prolyl oligopeptidase (POP) is a serine peptidase which digests … of how this family of proteins
functions in normal and in … pathway through intracellular calcium level fluctuations. PLC …
functions in normal and in … pathway through intracellular calcium level fluctuations. PLC …
Distribution of prolyl oligopeptidase in human peripheral tissues and body fluids
F Goossens, I De Meester, G Vanhoof, S Scharpé - 1996 - degruyter.com
… results from an interaction at die protein level, or has a genetic background. Specific and
biocompatible inhibitors for prolyl oligopeptidase should prove valuable in determining whether …
biocompatible inhibitors for prolyl oligopeptidase should prove valuable in determining whether …
Structure, function and biological relevance of prolyl oligopeptidase
L Polgar, Z Szeltner - Current Protein and Peptide Science, 2008 - ingentaconnect.com
… , the prolyl oligopeptidase family, cannot hydrolyze proteins and peptides containing more
than 30 residues. The crystal structure of prolyl oligopeptidase (POP) … Bcl-2 protein levels in 6…
than 30 residues. The crystal structure of prolyl oligopeptidase (POP) … Bcl-2 protein levels in 6…
… about the physiological functions of prolyl oligopeptidase based on its discordant spatial association with substrates and inconsistencies among mRNA, protein levels …
TT Myöhänen, JA García-Horsman… - … of Histochemistry & …, 2009 - journals.sagepub.com
Prolyl oligopeptidase (POP) is a serine endopeptidase that hydrolyses proline-containing
peptides shorter than 30 amino acids. POP may be associated with cognitive functions, …
peptides shorter than 30 amino acids. POP may be associated with cognitive functions, …
Oligopeptidases, and the emergence of the prolyl oligopeptidase family
AJ BARRETT, ND RAWLINGS - 1992 - degruyter.com
… was presumably the extremely low molar concentration of the susceptible terminal groups in
… of pig prolyl oligopeptidase was reported [21], no relationship to other proteins was apparent…
… of pig prolyl oligopeptidase was reported [21], no relationship to other proteins was apparent…
Prolyl oligopeptidase is involved in release of the antifibrotic peptide Ac-SDKP
MA Cavasin, NE Rhaleb, XP Yang, OA Carretero - Hypertension, 2004 - Am Heart Assoc
… Endogenous levels of Ac-SDKP in rats treated with POPi long-term. Amount of Ac-SDKP
per mg protein in heart and kidney cortex of rats chronically treated with vehicle (peanut oil), …
per mg protein in heart and kidney cortex of rats chronically treated with vehicle (peanut oil), …
A prolyl oligopeptidase inhibitor, KYP‐2047, reduces α‐synuclein protein levels and aggregates in cellular and animal models of Parkinson's disease
TT Myöhänen, MJ Hannula, R Van Elzen… - British journal of …, 2012 - Wiley Online Library
BACKGROUND AND PURPOSE The aggregation of α‐synuclein is connected to the pathology
of Parkinson's disease and prolyl oligopeptidase (PREP) accelerates the aggregation of …
of Parkinson's disease and prolyl oligopeptidase (PREP) accelerates the aggregation of …
Distribution of prolyl oligopeptidase in the mouse whole-body sections and peripheral tissues
TT Myöhänen, JI Venäläinen… - Histochemistry and cell …, 2008 - Springer
… and quantify POP protein at the macroscopic level in the mouse … of the protein and compare
the amounts of protein between the … Prolyl oligopeptidase protein was present in various cell …
the amounts of protein between the … Prolyl oligopeptidase protein was present in various cell …
[HTML][HTML] Prolyl oligopeptidase enhances α-synuclein dimerization via direct protein-protein interaction
MH Savolainen, X Yan, TT Myöhänen… - Journal of Biological …, 2015 - ASBMB
… Prolyl oligopeptidase (PREP) accelerates the aggregation of α-synuclein (aSyn), a key protein
… One mediator that enhances aSyn aggregation is prolyl oligopeptidase (PREP, POP, EC …
… One mediator that enhances aSyn aggregation is prolyl oligopeptidase (PREP, POP, EC …
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