Protein‐based artificial nanosystems in cancer therapy
N Zhang, K Mei, P Guan, X Hu, Y Zhao - Small, 2020 - Wiley Online Library
… [ 105 ] Herein, platinum nanoparticles acted as catalase mimics, while gold nanoparticles
with an ultrasmall size worked for GO X mimics. Supported porphyrin framework played roles …
with an ultrasmall size worked for GO X mimics. Supported porphyrin framework played roles …
Tumor cell vascular mimicry: Novel targeting opportunity in melanoma
MJC Hendrix, EA Seftor, REB Seftor, JT Chao… - … & therapeutics, 2016 - Elsevier
… Schematic model of signaling pathways implicated in tumor cell vascular mimicry (VM). … a
protein and/or downstream effector protein or proteins in modulating VM in aggressive cancer …
protein and/or downstream effector protein or proteins in modulating VM in aggressive cancer …
Tailoring peptidomimetics for targeting protein–protein interactions
ON Akram, DJ DeGraff, JH Sheehan, WD Tilley… - Molecular Cancer …, 2014 - AACR
… mimics) are small organic molecules bearing an identifiable resemblance to peptides or
peptide segments of proteins. … to interact with the same target protein of interest by arranging …
peptide segments of proteins. … to interact with the same target protein of interest by arranging …
Peptidomimetics: a synthetic tool for inhibiting protein–protein interactions in cancer
… and sheets at protein–protein interfaces, application of β-strand or β-sheet mimics as
modulators of PPI is limited. Strand designs are challenging because mimics with appropriately …
modulators of PPI is limited. Strand designs are challenging because mimics with appropriately …
Protein domain mimics as modulators of protein–protein interactions
… and tertiary protein domain mimics (PDMs) to specifically modulate PPIs. … mimics described
in this paper. He is also cofounder of Inthera Bioscience, which is pursuing therapeutic …
in this paper. He is also cofounder of Inthera Bioscience, which is pursuing therapeutic …
α-Helix mimetics as inhibitors of protein–protein interactions
I Saraogi, AD Hamilton - Biochemical Society Transactions, 2008 - portlandpress.com
… Our strategy for the design of such agents involves the mimicry of side-chain residues on
one face of the α-helix; these residues frequently play a key role in mediating protein–protein …
one face of the α-helix; these residues frequently play a key role in mediating protein–protein …
Overview of advances in vasculogenic mimicry–a potential target for tumor therapy
H Ge, H Luo - Cancer management and research, 2018 - Taylor & Francis
Vasculogenic mimicry (VM) describes the process utilized by highly aggressive cancer cells
to generate vascular-like structures without the presence of endothelial cells. VM has been …
to generate vascular-like structures without the presence of endothelial cells. VM has been …
Cancer stem cell mimicry for immune evasion and therapeutic resistance
PE Saw, Q Liu, PP Wong, E Song - Cell Stem Cell, 2024 - cell.com
… state represents “mimicry” by cancer cells that leads to phenotypic plasticity. CSC mimicry
is … , or lymphangiogenic cells to support cancer growth. CSCs facilitate both paracrine and …
is … , or lymphangiogenic cells to support cancer growth. CSCs facilitate both paracrine and …
Direct molecular mimicry enables off-target cardiovascular toxicity by an enhanced affinity TCR designed for cancer immunotherapy
MCC Raman, PJ Rizkallah, R Simmons, Z Donnellan… - Scientific reports, 2016 - nature.com
… unrelated epitope from the Titin protein presented on cardiac tissue… mimicry leading to
clinically relevant fatal toxicity, mediated by a modified enhanced affinity TCR designed for cancer …
clinically relevant fatal toxicity, mediated by a modified enhanced affinity TCR designed for cancer …
Synthetic antibody mimics for the inhibition of protein–ligand interactions
C Haußner, J Lach, J Eichler - Current opinion in chemical biology, 2017 - Elsevier
… of proteins that recognize a wide range of targets in therapeutic, diagnostic and research-based
applications. During the past decade, the number of antibodies approved for clinical use …
applications. During the past decade, the number of antibodies approved for clinical use …