… specific multi-protein assemblies or … protein interaction interfaces (the molecular surfaces
through which subunits of multiprotein complexes make contact with one other) as being large, …

… The huge diversity of PPIs and corresponding protein–protein interfaces means that it is …
protein–protein interface brings to mind the large surfaces that are present in globular protein …

… protein interaction surfaces are large and complicated, only a few specific regions of the
interface … Similar studies performed on other protein-protein complexes have provided evidence …

… Protein–protein interfaces are frequently hydrophobic and bury a large extent of nonpolar
surface area.… Hence, hydrophobicity is a leading force in protein–protein interactions.30, 31 …

… sites were shown to frequently be the largest cavities on the enzyme surface (6, 7). … protein
surface. Native binding sites do not yield the largest possible interfaces between two protein …

… The largest change in hot spot solvent-accessible surface area we find is 4.2 Å 2 for the
shaved mutant hGH receptor [B+C+D] (S98A, S102A, E120A, K121A, Q166A, K167A and V171A)…

… of other hydrophobic interaction sites on the surface of the protein. In some of the large
protomers of the hetero-complexes the interfaces tended to be amongst the least protruding …

… in targeting the interfaces between interacting proteins for therapeutic … interfaces make this
task a huge challenge. The contact surfaces involved in protein–protein interactions are large (…

… Twenty complexes have “large” interfaces burying 2000 to 4660 Å 2 , and large …
association: the size and chemical character of the protein surface that is buried at interfaces…

… As a result, the field of proteins at interfaces displays as much … both to the particular
protein/surface system studied and to … By and large these surfaces do not adsorb the target protein …