The unfolded protein response
CY Liu, RJ Kaufman - Journal of cell science, 2003 - journals.biologists.com
… If the protein-folding defect is not corrected, cells undergo apoptosis (light-blue … protein
kinase that phosphorylates the α subunit of translation initiation factor 2 (eIF2α) in response to ER …
kinase that phosphorylates the α subunit of translation initiation factor 2 (eIF2α) in response to ER …
Mechanisms, regulation and functions of the unfolded protein response
C Hetz, K Zhang, RJ Kaufman - Nature reviews Molecular cell biology, 2020 - nature.com
… the unfolded protein response (UPR), a signal transduction pathway that senses the fidelity
of protein folding in the ER lumen. The UPR transmits information about protein folding status …
of protein folding in the ER lumen. The UPR transmits information about protein folding status …
The mammalian unfolded protein response
M Schröder, RJ Kaufman - Annu. Rev. Biochem., 2005 - annualreviews.org
… When protein folding in the ER is inhibited, signal transduction pathways, which increase …
the unfolded protein response (UPR). In this review, we briefly summarize principles of protein …
the unfolded protein response (UPR). In this review, we briefly summarize principles of protein …
[PDF][PDF] Unfolded protein response
SS Cao, RJ Kaufman - Current biology, 2012 - cell.com
… As our understanding of ER protein-folding pathways and the mechanisms of UPR signaling
of adaptive and apoptotic responses has grown, so has the significance of their impact on …
of adaptive and apoptotic responses has grown, so has the significance of their impact on …
The impact of the unfolded protein response on human disease
S Wang, RJ Kaufman - Journal of Cell Biology, 2012 - rupress.org
… proteins in the ER. To maintain ER homeostasis, eukaryotic cells have evolved the unfolded
protein response (… , oxidative stress, and inflammatory response pathways. The UPR has …
protein response (… , oxidative stress, and inflammatory response pathways. The UPR has …
Targeting the unfolded protein response in disease
… response known as the unfolded protein response (UPR). Three major stress sensors control
UPR-dependent responses: inositol-requiring enzyme 1α (IRE1α), protein kinase … proteins …
UPR-dependent responses: inositol-requiring enzyme 1α (IRE1α), protein kinase … proteins …
The role of the unfolded protein response in tumour development: friend or foe?
Y Ma, LM Hendershot - Nature Reviews Cancer, 2004 - nature.com
… cells and that the cellular responses to destroy the damaged … response pathways, including
the unfolded protein response … maturation of secretory-pathway proteins 1 . Many aspects of …
the unfolded protein response … maturation of secretory-pathway proteins 1 . Many aspects of …
A review of the mammalian unfolded protein response
A Chakrabarti, AW Chen… - Biotechnology and …, 2011 - Wiley Online Library
… protein folding by an inbuilt quality control system involving both the ER and the Golgi apparatus.
Unfolded or misfolded proteins … proteins can also trigger the unfolded protein response (…
Unfolded or misfolded proteins … proteins can also trigger the unfolded protein response (…
[HTML][HTML] Orchestrating the unfolded protein response in health and disease
RJ Kaufman - The Journal of clinical investigation, 2002 - Am Soc Clin Investig
… protein-folding capacity is not overwhelmed. These pathways, collectively termed the unfolded
protein response (… , elevated secretory protein synthesis, expression of misfolded proteins, …
protein response (… , elevated secretory protein synthesis, expression of misfolded proteins, …
ER stress and the unfolded protein response
M Schröder, RJ Kaufman - Mutation Research/Fundamental and Molecular …, 2005 - Elsevier
… proteins disrupts protein folding in the endoplasmic reticulum (ER), causes ER stress, and
activates a signaling network called the unfolded protein response … secreted proteins. Here we …
activates a signaling network called the unfolded protein response … secreted proteins. Here we …