The unfolded protein response: controlling cell fate decisions under ER stress and beyond

C Hetz - Nature reviews Molecular cell biology, 2012 - nature.com
… determine divergent cell fate decisions. … cell fate decisions. Current models of the mechanisms
that might underlie the initiation, attenuation and fine-tuning of UPR-dependent responses

[HTML][HTML] Redox signaling and unfolded protein response coordinate cell fate decisions under ER stress

Z Zhang, L Zhang, L Zhou, Y Lei, Y Zhang, C Huang - Redox biology, 2019 - Elsevier
protein response (UPR) pathways with an aim to initially restore homeostasis by activating
genes involved in protein … Over time, however, activated UPR involves a variety of cellular

The unfolded protein response and cell fate control

C Hetz, FR Papa - Molecular cell, 2018 - cell.com
… , cells employ a dynamic intracellular signaling pathway known as the unfolded protein response
… of ER stress stimuli in order to control cell fate. These findings are timely and significant …

Endoplasmic reticulum stress, the unfolded protein response, autophagy, and the integrated regulation of breast cancer cell fate

R Clarke, KL Cook, R Hu, COB Facey, I Tavassoly… - Cancer research, 2012 - AACR
… of autophagy and apoptosis in regulating tumor cell fate, as clearly highlighted in this review,
… of cell fate proposed in this review may be broadly applicable to many different cell types. …

Transition states and cell fate decisions in epigenetic landscapes

N Moris, C Pina, AM Arias - Nature Reviews Genetics, 2016 - nature.com
cell fate specification process is the mechanism by which cells make a choice, the so-called
cell fate decision… is binary 12 and steers cells to adopt one of two cell states, thus enabling …

The UPR and cell fate at a glance

PI Merksamer, FR Papa - Journal of Cell Science, 2010 - journals.biologists.com
… UPR influences cell fate by promoting either cell adaptation or apoptosis when protein folding
… Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response

Cell fate decisions: emerging roles for metabolic signals and cell morphology

S Tatapudy, F Aloisio, D Barber, T Nystul - EMBO reports, 2017 - embopress.org
… to regulating cell fate decisions. These cues … cell fate decisions are influenced by four
aspects of cell biology: metabolism, reactive oxygen species (ROS), intracellular pH (pHi), and cell

Linking the cell cycle to cell fate decisions

S Dalton - Trends in cell biology, 2015 - cell.com
… This suggests a broad biological mechanism where multipotent cells are ‘primed’ to
initiate cell fate decisions during their transition through G1. Here, I discuss mechanisms …

Regulated cell-to-cell variation in a cell-fate decision system

A Colman-Lerner, A Gordon, E Serra, T Chin… - Nature, 2005 - nature.com
… Here we studied cell-to-cell variation, not in gene expression, but in … cell-fate decision
system: the pheromone response pathway in the yeast Saccharomyces cerevisiae. In haploid cells

Mathematical modelling of cell-fate decision in response to death receptor engagement

L Calzone, L Tournier, S Fourquet… - PLoS computational …, 2010 - journals.plos.org
cell lines and cellular conditions. The mechanistic details of how a cell chooses among these
cell fates … a mathematical model of cell fate decision recapitulating and integrating the most …