… cellular responses to endoplasmic reticulum (ER) stress is the activation of the unfolded protein
response (… In spite of this, our knowledge of the molecular mechanisms that regulate cell …

… p53 is regulated both at the levels of protein stability and biochemical activities. This … cellular
proteins. This review discusses this intriguing complexity which affects the cell response to …

… , and to alleviate the burden on the organelle by reducing the amount of protein inside …
protein response (UPR), a transcription-dependent induction of ER lumenal chaperone proteins …

… responses such as the heat shock response or the unfolded protein response mediate an
increase in chaperone protein activity which enhances the protein folding capacity of the cell, …

… ) challenges, leading to activation of stress response pathways. The unfolded protein
response (UPR) is the cellular response to endoplasmic reticulum (ER) stress and plays a pivotal …

… cell stress response, the unfolded protein response, which is aimed initially at compensating
for damage but can eventually trigger cell death … stress leads to cell death remain enigmatic, …

… Changes in protein levels and the folded states of proteins are sensed by molecular
chaperones and the degradative machinery that function to maintain cellular protein homeostasis. …

… folding in the ER is a dynamic process buffered and modulated by several intracellular
signaling pathways that as a whole are known as the unfolded protein response (UPR) [ …

… of cell division. A more enduring explanation of the link between cell proliferation and cell
death … the cell's proliferative machinery—cell proliferative and apoptotic pathways are coupled. …

… degrade several crucial cellular proteins. Alternatively, small amounts of caspase 8 depend
on cleavage of the proapoptotic BH3-only protein Bid to induce cell death. This truncated …