… to protein-folding stress is mediated by the activation of an integrated signal transduction
pathway known as the unfolded protein response … stress of unfolded proteins. The differences in …

… Loss of protein folding homeostasis features many of the … (ER), the unfolded protein response
(UPR) comprises a set of … Surprisingly, the fine-tuning of the PERK output in G93A SOD1-…

… it allows a favorable environment for protein folding, in addition … protein folding, activating
the unfolded protein response (… mitochondrial metabolism and also fine-tunes the threshold to …

… cellular protein regulation works by fine-tuning the conformational state space of proteins. …
Each of them affects conformational thermodynamics and kinetics to fine-tune the protein …

Interferon responses are balanced between protection against pathogens and other
disease agents versus toxicity and development of chronic diseases. Optimal outcomes are …

… ing increased diversity of antigenic peptides for flexible and fine-tuned immune response. …
positions within a protein, with both N- and C-flanking residues. Each protein possesses its …

The phosphoinositide 3‐kinase (PI3K) family of lipid kinases regulates diverse aspects of
lymphocyte behavior. This review discusses how genetic and pharmacological tools have …

… fine-tuning of GPCR function can be attributed in many cases to receptor-interacting
proteins that … as scaffolds to modulate G protein-mediated signalling. Furthermore, GPCR-interacting …

… High recombinant protein secretion in CHO producer clones triggers the … protein response
(UPR), an intracellular response to the accumulation of unfolded and misfolded proteins in the …

… A first possibility is that newly synthesized P2 proteins are casually located on the cell …
of P2 proteins demonstrating economic efficiency and involving a process of “fine-tuning”, a …