… response to cellular stress, a well-established signaling cascade, the unfolded protein response
… Here, we review the distinct functions of the ER and UPR from a metabolic point of view, …

… — cumulatively called the unfolded protein response (UPR). Together, at least … metabolism
of proteins, amino acids and lipids. The arms of the UPR are integrated to provide a response …

… integrated stress response initiated by eIF2α phosphorylation that insures supply of amino
acids for protein … Activation of this integrated stress response is shown to have a special role …

… the genes, gene products, and metabolic substrates required for function of this process and
… protein responses, describe an ongoing attempt to systematically explain these responses …

… Aspects of the partioning of tissue glucose metabolism are shown in Fig. 1; for reviews,
see … Glucose and free fatty acid metabolism in non-insulin-dependent diabetes mellitus - …

… controls metabolism has not yet been fully explored. In this work, we address this problem
by integrating a large number of experimental data sets with a model of the metabolism of …

… developed a prototypic integrated system comprising signaling, metabolic, and regulatory …
efficiently scaled to integrated intracellular systems that incorporate signaling, metabolic, and …

… The structure of the metabolic system (ie, stoichiometries and … is obtained by integrating
metabolic fluxes, concentrations, … synthesis pathway: the integration of metabolic data has little …

Mitochondrial dysfunction is associated with activation of the integrated stress response (ISR)
but the underlying triggers remain unclear. We systematically combined acute …

… Our MADE algorithm integrates gene or protein expression data and a metabolic model
without a priori determination of activity thresholds. MADE can be applied to any set of two or …