… and responding to alterations in the ER protein … protein response (UPR). This molecular
transduction system monitors the protein-folding capacity of the ER and signals cell responses …

… , unfolded proteins accumulates within the ER. The unfolded protein response (UPR) is a
fundamental cellular process that is triggered by the accumulation of unfolded proteins within …

… or misfolded proteins in the endoplasmic reticulum (ER). ER proteostasis is governed by
the unfolded protein response (UPR), a signalling pathway that adjusts the protein-folding …

… The ERAD pathway is constitutively active, because of synthetic lethalities of loss-of-function
mutations in ERAD and the unfolded protein response (UPR) in yeast [53, 54]. ER stress …

… One of the early cellular responses to endoplasmic reticulum (ER) stress is the activation
of the unfolded protein response (UPR). ER stress and the UPR are both implicated in …

… Such an increase of unfolded proteins is termed “ER stress” and can have … ER stress and
maintain protein homeostasis, eukaryotic cells have evolved the unfolded protein response (…

… protein folding in the endoplasmic reticulum cause ER stress and activate a set of signaling
pathways termed the Unfolded Protein Response (… of unfolded proteins through upregulation …

… endoplasmic reticulum (ER) homeostasis results in a stress condition termed “ER stress”
determining the activation of a finely regulated program defined as unfolded protein response (…

… unfolded or misfolded proteins, and these pathways are collectively known as the
unfolded-protein response. New observations suggest that the unfolded-protein response can initiate …

… ER chaperones, enzymes, and structural components of the ER and came to be known as
the unfolded protein response (UPR) (ref. 2; also see Kaufman, this Perspective series, ref. 6). …