… Endoplasmic reticulum (ER) stress and unfolded protein response (UPR) constitute a
homeostatic response to accumulation of misfolded protein as well as numerous other …

… stress sensor pathway termed as unfolded protein response (UPR) through complex signaling
network of Protein kinase R-like endoplasmic reticulum … 1α-X-box-binding protein 1 (IRE1-…

… response (HSR) that manages cytosolic denatured proteins via … unfolded protein response
(UPR mt ) that facilitates protein … of mitochondrial heat-shock proteins, including mtHSP70 and …

… Protein misfolding is prominent in early cellular pathology of Alzheimer’s disease (AD), …
significance of endoplasmic reticulum stress/unfolded protein response (ER stress/UPR) and …

… Unfolded protein response (UPR) is an adaptive response which is used for re-establishing
protein homeostasis, and it is triggered by endoplasmic reticulum (ER) stress. Specific ER …

… This stress induces a cyto-protective signaling cascades termed … protein response (UPR)
aimed at restoring homeostasis. While acute ER stress is lethal, chronic sub-lethal ER stress …

… The PERK arm of the unfolded protein response (UPR) protects mitochondria during ER stress
through … Here, we show that ER stress also induces dynamic remodeling of mitochondrial …

… reticulum (ER) functioning, our data highlighted a defensive role for the unfolded protein
response (UPR… of aberrantly folded proteins through translation arrest, production of chaperone …

… Recent studies have shed light on the pivotal role of prolonged endoplasmic reticulum stress
(ERS)-initiated activation of the unfolded protein response (UPR), the ensuing chronic low-…

… protein response, which also intersects with the integrated stress response that reduces protein
… Central to the unfolded protein response are the sensors PERK, IRE1 and ATF6, as well …