… IRE1 is a prototype ER stress sensor that is evolutionarily … sensors, PERK and ATF6. This
review focuses on the current progress in our understanding of stress-sensing mechanisms, in …

… sensing mechanism, cells increase the abundance of these rare tRNAs under stress … a
highly conserved adaptive response referred to as the unfolded protein response (UPR). …

… Sensing stress and responding to stress … may function without a need for a sensing mechanism.
They could be dependent on a regulatory protein, presumably one of the components of …

… Structural homology suggests that the mechanism of IRE1 and PERK … proteins or integrate
other characteristics of ER stress. We anticipate that the ER stress-sensing mechanisms of …

… downstream responses, orchestrating adaptation to ER stress. … mechanisms underlying UPR
signaling, stress sensing, and … ER stress-sensing mechanism by IRE1α. Several models are …

… Here we show that ER Ca 2+ depletion stress, a triggering mechanism for the UPR,
induces the formation of ATF6(f), which represents de novo partial glycosylation of newly …

Upon endoplasmic reticulum (ER) stress, ER-located transmembrane stress sensors evoke …
protective responses. Although ER stress-dependent activation of the sensor proteins is …

… under nucleolar stress, and greatly compromised the activation of p53. In sum, our findings
provide a redox mechanism underlying the nucleolar stress sensing by NPM1 31 (Figure 4). …

… , and is known as the ER stress response or the unfolded protein response (UPR). The
intracellular … in one of the aforementioned stress-sensing mechanisms. The thiolreducing reagent …

… proteins. Here we review our current understanding of how an unfolded protein signal is
generated, sensed… how downstream events in this stress response are regulated. We propose a …