Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses
Adjuvants are critical for improving the quality and magnitude of adaptive immune responses
to vaccination. Lipid nanoparticle (LNP)-encapsulated nucleoside-modified mRNA …
to vaccination. Lipid nanoparticle (LNP)-encapsulated nucleoside-modified mRNA …
Lipid nanoparticles in the development of mRNA vaccines for COVID-19
… Lipid nanoparticles (LNPs) have great potential to deliver nucleic acids including mRNAs.
The two … The S protein (crown like) consist of two subunits namely S1 and S2 subunits. The S1 …
The two … The S protein (crown like) consist of two subunits namely S1 and S2 subunits. The S1 …
The role of lipid components in lipid nanoparticles for vaccines and gene therapy
CH Albertsen, JA Kulkarni, D Witzigmann… - Advanced drug delivery …, 2022 - Elsevier
… and rapid translational potential of lipid nanoparticles (LNPs). … ionizable cationic lipids in
addition to other types of lipids and … affect the protein corona composition on nanoparticles but …
addition to other types of lipids and … affect the protein corona composition on nanoparticles but …
Co-administration of lipid nanoparticles and sub-unit vaccine antigens is required for increase in antigen-specific immune responses in mice
EA Thoryk, G Swaminathan, S Meschino, KS Cox… - Vaccines, 2016 - mdpi.com
… A vast body of evidence suggests that nanoparticles function as potent immune-modulatory …
Lipid NanoParticles (LNPs) markedly boost B-cell and T-cell responses to sub-unit vaccine …
Lipid NanoParticles (LNPs) markedly boost B-cell and T-cell responses to sub-unit vaccine …
Construction of messenger RNA (mRNA) probes delivered by lipid nanoparticles to visualize intracellular protein expression and localization at organelles
… in vivo when delivered by lipid nanoparticles (LNPs). … subunits in charge of specific cellular
functions. [ 1, 2 ] Researchers have found that a number of organelle-associated proteins are …
functions. [ 1, 2 ] Researchers have found that a number of organelle-associated proteins are …
A novel lipid nanoparticle adjuvant significantly enhances B cell and T cell responses to sub-unit vaccine antigens
G Swaminathan, EA Thoryk, KS Cox, S Meschino… - Vaccine, 2016 - Elsevier
… Overall, our results demonstrate that lipid nanoparticles can serve as future sub-unit … lipid
nanoparticles have emerged as an excellent platform for delivery of adjuvants and protein …
nanoparticles have emerged as an excellent platform for delivery of adjuvants and protein …
Lipid nanoparticle technologies for the study of G protein-coupled receptors in lipid environments
S Lavington, A Watts - Biophysical Reviews, 2020 - Springer
… Here, we review the application of lipid nanoparticle technologies to the study of GPCRs, …
the G protein, the α-subunit αN helix runs along the nanodisc surface, residues of the γ-subunit …
the G protein, the α-subunit αN helix runs along the nanodisc surface, residues of the γ-subunit …
Lung-selective mRNA delivery of synthetic lipid nanoparticles for the treatment of pulmonary lymphangioleiomyomatosis
… Here, we have developed a library of N-series lipid nanoparticles (LNPs) that could specifically
regulate the protein composition of protein corona on the surface of LNPs, which allows …
regulate the protein composition of protein corona on the surface of LNPs, which allows …
Development and applications of mRNA treatment based on lipid nanoparticles
Z Wang, W Ma, X Fu, Y Qi, Y Zhao, S Zhang - Biotechnology Advances, 2023 - Elsevier
… protein subunit vaccines in mice. Excitingly, LNP formula performs better as an adjuvant
than the widely used MF59-like adjuvant, AddaVax. The adjuvant activity of LNP depends on …
than the widely used MF59-like adjuvant, AddaVax. The adjuvant activity of LNP depends on …
Optimization of lipid nanoparticles for intramuscular administration of mRNA vaccines
KJ Hassett, KE Benenato, E Jacquinet, A Lee… - … Therapy-Nucleic Acids, 2019 - cell.com
… protein expression or immunogenicity for DOTAP-containing LNPs (Figure 2A). Many of
our novel biodegradable lipids proved superior to MC3 for both protein … between protein …
our novel biodegradable lipids proved superior to MC3 for both protein … between protein …
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