Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses

MG Alameh, I Tombácz, E Bettini, K Lederer… - Immunity, 2021 - cell.com
Adjuvants are critical for improving the quality and magnitude of adaptive immune responses
to vaccination. Lipid nanoparticle (LNP)-encapsulated nucleoside-modified mRNA …

Lipid nanoparticles in the development of mRNA vaccines for COVID-19

B Wilson, KM Geetha - Journal of Drug Delivery Science and Technology, 2022 - Elsevier
Lipid nanoparticles (LNPs) have great potential to deliver nucleic acids including mRNAs.
The two … The S protein (crown like) consist of two subunits namely S1 and S2 subunits. The S1 …

The role of lipid components in lipid nanoparticles for vaccines and gene therapy

CH Albertsen, JA Kulkarni, D Witzigmann… - Advanced drug delivery …, 2022 - Elsevier
… and rapid translational potential of lipid nanoparticles (LNPs). … ionizable cationic lipids in
addition to other types of lipids and … affect the protein corona composition on nanoparticles but …

Co-administration of lipid nanoparticles and sub-unit vaccine antigens is required for increase in antigen-specific immune responses in mice

EA Thoryk, G Swaminathan, S Meschino, KS Cox… - Vaccines, 2016 - mdpi.com
… A vast body of evidence suggests that nanoparticles function as potent immune-modulatory …
Lipid NanoParticles (LNPs) markedly boost B-cell and T-cell responses to sub-unit vaccine …

Construction of messenger RNA (mRNA) probes delivered by lipid nanoparticles to visualize intracellular protein expression and localization at organelles

W Zhao, C Zeng, J Yan, S Du, X Hou… - Advanced …, 2021 - Wiley Online Library
… in vivo when delivered by lipid nanoparticles (LNPs). … subunits in charge of specific cellular
functions. [ 1, 2 ] Researchers have found that a number of organelle-associated proteins are …

A novel lipid nanoparticle adjuvant significantly enhances B cell and T cell responses to sub-unit vaccine antigens

G Swaminathan, EA Thoryk, KS Cox, S Meschino… - Vaccine, 2016 - Elsevier
… Overall, our results demonstrate that lipid nanoparticles can serve as future sub-unitlipid
nanoparticles have emerged as an excellent platform for delivery of adjuvants and protein

Lipid nanoparticle technologies for the study of G protein-coupled receptors in lipid environments

S Lavington, A Watts - Biophysical Reviews, 2020 - Springer
… Here, we review the application of lipid nanoparticle technologies to the study of GPCRs, …
the G protein, the α-subunit αN helix runs along the nanodisc surface, residues of the γ-subunit

Lung-selective mRNA delivery of synthetic lipid nanoparticles for the treatment of pulmonary lymphangioleiomyomatosis

M Qiu, Y Tang, J Chen, R Muriph… - Proceedings of the …, 2022 - National Acad Sciences
… Here, we have developed a library of N-series lipid nanoparticles (LNPs) that could specifically
regulate the protein composition of protein corona on the surface of LNPs, which allows …

Development and applications of mRNA treatment based on lipid nanoparticles

Z Wang, W Ma, X Fu, Y Qi, Y Zhao, S Zhang - Biotechnology Advances, 2023 - Elsevier
protein subunit vaccines in mice. Excitingly, LNP formula performs better as an adjuvant
than the widely used MF59-like adjuvant, AddaVax. The adjuvant activity of LNP depends on …

Optimization of lipid nanoparticles for intramuscular administration of mRNA vaccines

KJ Hassett, KE Benenato, E Jacquinet, A Lee… - … Therapy-Nucleic Acids, 2019 - cell.com
protein expression or immunogenicity for DOTAP-containing LNPs (Figure 2A). Many of
our novel biodegradable lipids proved superior to MC3 for both protein … between protein