… Mammalian carboxylesterases (CEs) are enzymes with broad substrate specificities that
have key roles in the metabolism of a wide variety of clinical drugs, illicit narcotics and chemical …

… sequence of the mammalian carboxylesterases shows that … and classification of mammalian
carboxylesterase. Until … valid links among the mammalian carboxylesterase gene family or …

… information regarding the structural characterization of the mammalian enzymes has only
been recently presented. For example, while the genes that encode these proteins in humans …

… of proteins. The majority of mammalian carboxylesterases are intracellular proteins found …
in mammalian cells 26 . Following cleavage of the C-terminal signal peptide, microsomal …

… Mammalian carboxylesterases are a family of proteins encoded by multiple genes. The six
human carboxylesterase … A large number of rodent carboxylesterase genes were generated …

… Carboxylesterases (CESs) are an important class of enzymes for biotransformation of
drugs, endogenous substrates, and environmental chemicals that contain esters, amides, …

… abundantly expressed in the mammalian liver. Several highly … Two major carboxylesterases
have been identified in human … to examine whether the human carboxylesterases hCE-1 and …

… of carboxylesterase isozymes, we propose a novel nomenclature and classification of mammalian
carboxylesterases on the … of carboxylesterases by xenobiotics, and the involvement of …

… Humans and small mammals demonstrate different levels of carboxylesterase expression. …
evolution, higher mammals (primates) have lost expression of these proteins in this fluid. …

… that determine the therapeutic efficacy and toxicity of ester/amide drugs. Without exceptions,
all mammalian species studied express multiple forms of carboxylesterases. Two human …