… Most exercise studies have assessed the regulation of stem cells and protein turnover to the
… that stem cell activation and increased protein turnover in response to protein ingestion and …

… stem cell function, but the complexities of the stem cell response to increases in damaged or
aggregated proteins remain … Here we demonstrate that adult neural stem cells (NSCs) utilize …

… In this work, we provide a robust methodology to measure protein turnover in iPSC-derived
organoids and compare differences across cell lines. As a test case, we compare wild type (…

… Similarly, the contribution of autophagy in embryonic stem cells is estimated to be about 2%/h
(73). These values might be underestimated, however, because some other degradation …

… are less equipped to resolve the high levels of protein … of protein turnover machinery led
to loss of the speed, magnitude, and efficacy of the cellular stress response in senescent cells. …

… The mechanisms ensuring proteostasis maintenance in adult stem cells from tissue with
high turnover (eg, the intestinal epithelium) has been so far explored in less detail. Intestinal …

… Low protein synthesis is a feature of somatic stem cells that … Modest increases in protein
synthesis impair stem cell function… that low protein synthesis within hematopoietic stem cells (…

… monitors proteins from their synthesis through their degradation. Whereas somatic stem
cells lose their ability to maintain proteostasis with age, immortal pluripotent stem cells exhibit a …

… , protein turnover refers specifically to the continuous degradation and renewal of intracellular
proteins that … amino acids, and replaced by an equal amount of freshly synthesized protein. …

… , where they act as a cell reserve that supports normal tissue turnover and can mount a …
Recent studies revealed that quiescent stem cells have a discordance between RNA and protein …