Impact of proton pump inhibitors and histamine-2-receptor antagonists on non-small cell lung cancer immunotherapy: a systematic review and meta-analysis

A Rizzo, A Cusmai, F Giovannelli, S Acquafredda… - Cancers, 2022 - mdpi.com
Simple Summary The current meta-analysis highlighted that proton pump inhibitors (PPIs)
and histamine-2-receptor antagonists (H2RAs) could impact immune checkpoint inhibitors (…

[HTML][HTML] Impact of proton-pump inhibitors on the efficacy of immune checkpoint inhibitors in non-small cell lung cancer: A systematic review and meta-analysis

S Dar, N Merza, M Rahim, A Qatani… - Annals of Medicine and …, 2022 - Elsevier
… Our study finds that Proton Pump Inhibitors worsen the outcomes of overall survival and … to
use proton pump inhibitors more judiciously in patients with Non-Small Cell Lung Carcinoma. …

The association between proton pump inhibitor use and systemic anti‐tumour therapy on survival outcomes in patients with advanced non‐small cell lung cancer: A …

N Wei, B Zheng, W Que, J Zhang… - British Journal of Clinical …, 2022 - Wiley Online Library
… The cancer with the highest morbidity and mortality is lung cancer. Non-small cell lung
cancer (NSCLC) accounts for a high proportion of all lung cancers (up to 85–90%). NSCLC …

Proton pump inhibitors reduce the survival of advanced lung cancer patients with therapy of gefitinib or erlotinib

CH Lee, MC Shen, MJ Tsai, JS Chang, YB Huang… - Scientific Reports, 2022 - nature.com
… We used ICD-O-3 code C33–C34 to identify patients with lung cancer in the TCR database
… with EGFR mutations, no prior cancer record before lung cancer diagnosis, and receiving first-…

Effects of Proton Pump Inhibitor Coadministration on the Plasma Concentration of Erlotinib in Patients With Non–Small Cell Lung Cancer

M Ohgami, T Kaburagi, A Kurosawa… - Therapeutic drug …, 2018 - journals.lww.com
… Erlotinib is used for treating non–small cell lung cancer (NSCLC). Intestinal absorption of …
We investigated the effects of erlotinib coadministration with proton pump inhibitors (PPIs) and …

Survival outcomes of patients with nonsmall cell lung cancer concomitantly receiving proton pump inhibitors and immune checkpoint inhibitors

YH Baek, EJ Kang, S Hong, S Park… - … Journal of Cancer, 2022 - Wiley Online Library
… of proton pump inhibitors (PPIs) and ICIs, and poor prognosis in patients with nonsmall …
lung cancer (NSCLC). We conducted a cohort study using a completely enumerated lung cancer

Efficacy of first-line atezolizumab combination therapy in patients with non-small cell lung cancer receiving proton pump inhibitors: post hoc analysis of IMpower150

AM Hopkins, G Kichenadasse, RA McKinnon… - … Journal of Cancer, 2022 - nature.com
Background Proton pump inhibitors (PPIs) are commonly used concomitant to cancer
treatment and they induce gut microbiota changes. It is increasingly apparent that gut dysbiosis …

[HTML][HTML] Efficacy of chemotherapy and atezolizumab in patients with non-small-cell lung cancer receiving antibiotics and proton pump inhibitors: pooled post hoc …

M Chalabi, A Cardona, DR Nagarkar, AD Scala… - Annals of …, 2020 - Elsevier
… Use of antibiotics or proton pump inhibitors in patients with non-small cell lung cancer is …
Preclinical data have shown that proton pump inhibitors (PPI) can modulate the microbiome, …

Concurrent proton-pump inhibitors increase risk of death for lung cancer patients receiving 1st-line gefitinib treatment-a nationwide population-based study

YH Fang, YH Yang, MJ Hsieh, MS Hung… - Cancer management …, 2019 - Taylor & Francis
lung cancer Using the NHIRD, we identified patients older than 18 years of age with lung
cancer … of NHIRD, and pathological confirmation of lung cancer is required to apply this registry. …

Clostridium butyricum therapy restores the decreased efficacy of immune checkpoint blockade in lung cancer patients receiving proton pump inhibitors

Y Tomita, Y Goto, S Sakata, K Imamura… - …, 2022 - Taylor & Francis
lung cancer (NSCLC) patients treated with ICB and analyzed 80 fecal samples of patients
with lung cancer … shown to improve the ICB efficacy in lung cancer. Thus, we investigated how …