… Pseudomonas aeruginosa. The bacteria underwent numerous genetic adaptations during 8
… genome and an overwhelming signal in specific genes, several of which are mutated during …

… During the second decade, Pseudomonas aeruginosa becomes the most dominant pathogen
… In this work, we describe the mechanisms used by P. aeruginosa to adapt and persist in …

… Furthermore, despite the fact that the effect of hypermutation on genetic adaptation and …
the contribution of hypermutation to the genetic adaptation of P. aeruginosa to the airways of CF …

… Most patients with the genetic disease cystic fibrosis (CF) succumb to chronic airway
infection caused by the bacterium Pseudomonas aeruginosa. CF lung disease follows a …

… that contribute to the rise and expansion of genetically heterogeneous adapted populations.
Despite this genetic diversity and unique evolutionary trajectories, populations of P. …

… in one or more previous studies on P. aeruginosa genetic adaptation in patients with CF
or PCD (Text S1). We found that mutations were observed more often in genes previously …

… molecular evolution of distinct clonal lineages of P. aeruginosa from initial invasion of cystic
fibrosis airways onward, as the lineages genetically adapted to a human host after transition …

… aeruginosa that expand under the selective pressure of … genes are among the most frequently
mutated genes during the adaptation process in the CF airway, and the specific genes that …

… change in chronic CF isolates that accounts for these adaptations is the mutational inactivation
of the lasR gene encoding the transcriptional quorum sensing (QS) regulator LasR. In the …

… of following the genetic adaptation of different clonal lineages by characterizing the
accumulation of loss-of-function mutations in mucA, lasR and six anti-mutator genes in longitudinal …