Pseudomonas aeruginosa is a remarkably versatile environmental bacterium with an
extraordinary capacity to infect the cystic fibrosis (CF) lung. Infection with P. aeruginosa
occurs early, and although eradication can be achieved following early detection, chronic
infection occurs in over 60% of adults with CF. Chronic infection is associated with
accelerated disease progression and increased mortality. Extensive research has revealed
complex mechanisms by which P. aeruginosa adapts to and persists within the CF airway …

Cystic fibrosis (CF) is a complex inherited disease which affects many organs, including the
pancreas and liver, gastrointestinal tract and reproductive system, sweat glands and,
particularly, the respiratory system. Pseudomonas aeruginosa is the main cause of chronic
airway infection. In order to reduce morbidity and mortality due to lung infection by P.
aeruginosa, aerosol antibiotics have been used to achieve high local concentrations in the
airways and to reduce systemic toxicity. In the course of this review, the current treatments to …