Within-Host Adaptation Mediated by Intergenic Evolution in Pseudomonas aeruginosa

SMH Khademi, P Sazinas… - … Biology and Evolution, 2019 - academic.oup.com
… within coding regions, whereas the role of intergenicintergenic mutations contribute to the
evolutionary response of a clinically important bacterial pathogen, Pseudomonas aeruginosa, …

Intergenic evolution during host adaptation increases expression of the metallophore pseudopaline in Pseudomonas aeruginosa

GMM Hermansen, ML Hansen… - …, 2018 - microbiologyresearch.org
… Iron homeostasis in Pseudomonas aeruginosa is important during infection, … evolutionary
role of naturally occurring intergenic mutations found in the promoter region of zrmABCD of P

The Genomic Basis of Rapid Adaptation to Antibiotic Combination Therapy in Pseudomonas aeruginosa

…, N Mahrt, J Bunk, M Graßer, P Rosenstiel… - … and evolution, 2021 - academic.oup.com
… Our work revealed a high potential effect of intergenic variants on resistance evolution. In
particular, we found several cases in which the surviving populations had a single variant in …

Evolution of Pseudomonas aeruginosa toward higher fitness under standard laboratory conditions

I Grekov, JG Thöming, A Kordes, S Häussler - The ISME journal, 2021 - academic.oup.com
aeruginosa, indels in intergenic homopolymeric tracts promote adaptation both, to our … of
mutations in the intergenic regions for the adaptation of P. aeruginosa to the conditions of cystic …

Host adaptation mediated by intergenic evolution in a bacterial pathogen

SM Hossein Khademi, L Jelsbak - bioRxiv, 2017 - biorxiv.org
… We characterize intergenic evolution in 44 lineages of a clinically … , Pseudomonas aeruginosa,
as they adapt to their hosts. We identify 88 intergenic regions in which parallel evolution

Within-host evolution of Pseudomonas aeruginosa reveals adaptation toward iron acquisition from hemoglobin

RL Marvig, S Damkiær, SMH Khademi, TM Markussen… - MBio, 2014 - Am Soc Microbiol
… evidence that within-host evolution of P. aeruginosa is characterized by adaptation toward
… We therefore focused on the intergenic regions with the highest densities of mutations and …

Pseudomonas aeruginosa Genome Evolution in Patients and under the Hospital Environment

…, S Elsen, C Bordi, K Jeannot, I Attrée, P Plésiat… - Pathogens, 2014 - mdpi.com
Pseudomonas aeruginosa is a Gram-negative environmental species and an opportunistic
… Herein is illustrated the intraclonal evolution of the genome of sequential isolates collected in …

Genome Analysis of a Transmissible Lineage of Pseudomonas aeruginosa Reveals Pathoadaptive Mutations and Distinct Evolutionary Paths of Hypermutators

RL Marvig, HK Johansen, S Molin, L Jelsbak - PloS genetics, 2013 - journals.plos.org
evolved independently for years in separate hosts, creating a unique possibility to study
parallel evolution … mutations correlates with evolutionary success of co-evolving sub-lineages. …

Evolution of Pseudomonas aeruginosa antimicrobial resistance and fitness under low and high mutation rates

G Cabot, L Zamorano, B Moyà, C Juan… - Antimicrobial agents …, 2016 - Am Soc Microbiol
Pseudomonas aeruginosa , a major cause of nosocomial and chronic infections, is considered
a paradigm of antimicrobial resistance development. However, the evolutionaryevolution

Coexistence and Within-Host Evolution of Diversified Lineages of Hypermutable Pseudomonas aeruginosa in Long-term Cystic Fibrosis Infections

S Feliziani, RL Marvig, AM Lujan, AJ Moyano… - PLoS …, 2014 - journals.plos.org
… to follow the genomic evolution of pathogenic bacteria by … airway infections by Pseudomonas
aeruginosa in cystic fibrosis (… system (MRS) deficiency, a common trait evolved by P. …