Within-Host Adaptation Mediated by Intergenic Evolution in Pseudomonas aeruginosa
SMH Khademi, P Sazinas… - … Biology and Evolution, 2019 - academic.oup.com
… within coding regions, whereas the role of intergenic … intergenic mutations contribute to the
evolutionary response of a clinically important bacterial pathogen, Pseudomonas aeruginosa, …
evolutionary response of a clinically important bacterial pathogen, Pseudomonas aeruginosa, …
Intergenic evolution during host adaptation increases expression of the metallophore pseudopaline in Pseudomonas aeruginosa
GMM Hermansen, ML Hansen… - …, 2018 - microbiologyresearch.org
… Iron homeostasis in Pseudomonas aeruginosa is important during infection, … evolutionary
role of naturally occurring intergenic mutations found in the promoter region of zrmABCD of P…
role of naturally occurring intergenic mutations found in the promoter region of zrmABCD of P…
The Genomic Basis of Rapid Adaptation to Antibiotic Combination Therapy in Pseudomonas aeruginosa
…, N Mahrt, J Bunk, M Graßer, P Rosenstiel… - … and evolution, 2021 - academic.oup.com
… Our work revealed a high potential effect of intergenic variants on resistance evolution. In
particular, we found several cases in which the surviving populations had a single variant in …
particular, we found several cases in which the surviving populations had a single variant in …
Evolution of Pseudomonas aeruginosa toward higher fitness under standard laboratory conditions
I Grekov, JG Thöming, A Kordes, S Häussler - The ISME journal, 2021 - academic.oup.com
… aeruginosa, indels in intergenic homopolymeric tracts promote adaptation both, to our … of
mutations in the intergenic regions for the adaptation of P. aeruginosa to the conditions of cystic …
mutations in the intergenic regions for the adaptation of P. aeruginosa to the conditions of cystic …
Host adaptation mediated by intergenic evolution in a bacterial pathogen
SM Hossein Khademi, L Jelsbak - bioRxiv, 2017 - biorxiv.org
… We characterize intergenic evolution in 44 lineages of a clinically … , Pseudomonas aeruginosa,
as they adapt to their hosts. We identify 88 intergenic regions in which parallel evolution …
as they adapt to their hosts. We identify 88 intergenic regions in which parallel evolution …
Within-host evolution of Pseudomonas aeruginosa reveals adaptation toward iron acquisition from hemoglobin
RL Marvig, S Damkiær, SMH Khademi, TM Markussen… - MBio, 2014 - Am Soc Microbiol
… evidence that within-host evolution of P. aeruginosa is characterized by adaptation toward
… We therefore focused on the intergenic regions with the highest densities of mutations and …
… We therefore focused on the intergenic regions with the highest densities of mutations and …
Pseudomonas aeruginosa Genome Evolution in Patients and under the Hospital Environment
…, S Elsen, C Bordi, K Jeannot, I Attrée, P Plésiat… - Pathogens, 2014 - mdpi.com
… Pseudomonas aeruginosa is a Gram-negative environmental species and an opportunistic
… Herein is illustrated the intraclonal evolution of the genome of sequential isolates collected in …
… Herein is illustrated the intraclonal evolution of the genome of sequential isolates collected in …
Genome Analysis of a Transmissible Lineage of Pseudomonas aeruginosa Reveals Pathoadaptive Mutations and Distinct Evolutionary Paths of Hypermutators
… evolved independently for years in separate hosts, creating a unique possibility to study
parallel evolution … mutations correlates with evolutionary success of co-evolving sub-lineages. …
parallel evolution … mutations correlates with evolutionary success of co-evolving sub-lineages. …
Evolution of Pseudomonas aeruginosa antimicrobial resistance and fitness under low and high mutation rates
… Pseudomonas aeruginosa , a major cause of nosocomial and chronic infections, is considered
a paradigm of antimicrobial resistance development. However, the evolutionary … evolution …
a paradigm of antimicrobial resistance development. However, the evolutionary … evolution …
Coexistence and Within-Host Evolution of Diversified Lineages of Hypermutable Pseudomonas aeruginosa in Long-term Cystic Fibrosis Infections
… to follow the genomic evolution of pathogenic bacteria by … airway infections by Pseudomonas
aeruginosa in cystic fibrosis (… system (MRS) deficiency, a common trait evolved by P. …
aeruginosa in cystic fibrosis (… system (MRS) deficiency, a common trait evolved by P. …
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