[HTML][HTML] Nasal oxytocin for the treatment of psychiatric disorders and pain: achieving meaningful brain concentrations

DC Yeomans, LR Hanson, DS Carson… - … psychiatry, 2021 - nature.com
… There is evidence of the therapeutic potential of intranasal oxytocin for the treatment of pain
and various psychiatric disorders, however, there is scant evidence that oxytocin reaches the …

The role of oxytocin in psychiatric disorders: a review of biological and therapeutic research findings

DM Cochran, D Fallon, M Hill… - … review of psychiatry, 2013 - journals.lww.com
… levels were also seen in patients who self-reported high daily levels of pain, stress, and …
intranasal oxytocin therapy (14.4 IU). However, this patient also developed psychotic symptoms

Oxytocin in the socioemotional brain: implications for psychiatric disorders

P Kirsch - Dialogues in clinical neuroscience, 2015 - Taylor & Francis
… During recent years, the neuropeptide oxytocin (OXT) has attracted enormous … of psychiatric
research, the number of publications focusing on OXT in the context of mental disorders has …

[HTML][HTML] Oxytocin: narrative expert review of current perspectives on the relationship with other neurotransmitters and the impact on the main psychiatric disorders

T Florea, M Palimariciuc, AC Cristofor, I Dobrin… - Medicina, 2022 - mdpi.com
… In these conditions, intranasal oxytocin … of pain is not equal between individuals, even
when applying the same stimulus, and the perception of pain is influenced by the psychological

[HTML][HTML] Oxytocin in the Treatment of Psychiatric Disorders

SC Kagizman, C Hocaoglu - Medeniyet Medical Journal, 2023 - ncbi.nlm.nih.gov
… After 24 international unit (IU) intranasal oxytocin administration twice a day for 12 weeks …
that thermal pain decreased with oxytocin administration to patients with chronic low back pain, …

[HTML][HTML] Intranasal administration for pain: oxytocin and other polypeptides

VN Bharadwaj, AZ Tzabazis, M Klukinov, NA Manering… - Pharmaceutics, 2021 - mdpi.com
nasal–cerebral pathway. We review recent studies that demonstrate that polypeptides such
as oxytocin, delivered IN, not only reach key pain-… chronic pain treatment and management. …

Intranasal oxytocin administration is associated with enhanced endogenous pain inhibition and reduced negative mood states

BR Goodin, AJB Anderson, EL Freeman… - … journal of pain, 2015 - journals.lww.com
… such as hypnosis and meditation, which have been shown to produce feelings of
psychological well-being that are mediated by oxytocin. Taken together, the findings relating …

Oxytocin nasal spray in fibromyalgic patients

S Mameli, GM Pisanu, S Sardo, A Marchi, A Pili… - Rheumatology …, 2014 - Springer
… involved in the modulation of pain and in motivation, sense of … studies showed that oxytocin
reduced the severity of pain [8, … psychiatric assessment to investigate the presence of mental

Effects of intranasal oxytocin on thermal pain in healthy men: a randomized functional magnetic resonance imaging study

M Zunhammer, S Geis, V Busch… - Psychosomatic …, 2015 - journals.lww.com
… who found that intranasal oxytocin reduces pain intensity ratings, pain unpleasantness ratings…
-pressor pain. Although Kessner et al. ( 7 ) found no effect of oxytocin on heat pain ratings, …

Intranasal oxytocin alleviates comorbid depressive symptoms in neuropathic pain via elevating hippocampal BDNF production in both female and male mice

R Liu, D Sun, X Xing, Q Chen, B Lu, B Meng, H Yuan… - …, 2024 - Elsevier
… of oxytocin on chronic pain comorbidities of mental disorders are not well understood. An
investigation using rodent models of inflammatory pain indicates that intrathecal oxytocinpain