The pathophysiology of major depressive disorder through the lens of systems biology: Network analysis of the psycho-immune-neuroendocrine physiome

NJC Stapelberg, TA Bui, V Mansour, S Johnson… - Journal of …, 2022 - Elsevier
… A directed network graph of the psycho-immune-neuroendocrine network is provided. … Whilst
the concept is thus arguably established in the literature, no structural network analysis has …

Stress and the psyche–brain–immune network in psychiatric diseases based on psychoneuroendocrineimmunology: a concise review

AG Bottaccioli, F Bottaccioli… - Annals of the New York …, 2019 - Wiley Online Library
… A major factor that can profoundly affect the psycho-neuro-endocrine-immune network is …
on nervous, immune, endocrine, and metabolic systems.10 Many psychosocial conditions …

Health, pre-disease and critical transition to disease in the psycho-immune-neuroendocrine network: Are there distinct states in the progression from health to major …

NJC Stapelberg, DL Neumann, D Shum… - Physiology & …, 2019 - Elsevier
network analysis of … network approach to the analysis of causal and other linkages between
symptoms can enhance the classification of psychopathology [23]. Furthermore, the network

From feedback loop transitions to biomarkers in the psycho-immune-neuroendocrine network: Detecting the critical transition from health to major depression

NJC Stapelberg, R Pratt, DL Neumann… - Neuroscience & …, 2018 - Elsevier
… (CNS), immune, endocrine and autonomic networks. These constituent networks have been
… For example, networks modulating immune, autonomic and endocrine functions have been …

From physiome to pathome: a systems biology model of major depressive disorder and the psycho-immune-neuroendocrine network

NJC Stapelberg, DL Neumann… - Current psychiatry …, 2015 - ingentaconnect.com
psycho-immune-neuroendocrine (PINE) network. It provides a comprehensive synthesis of
the networkNetwork analysis is a formalized methodology used to characterize the structure …

The Network Paradigm: New Niches for Psychosomatic Medicine

I Lázár - Psychosomatic Medicine, 2020 - books.google.com
… or competing schools of psychosomatic medical philosophy, … of “decoding” the socio-psycho-immune
network. This is how … This means a network analysis of social behavioral cognitive …

Consequences of stress on the psycho-immune-neuro-energy network: On the search for novel biomarkers and protective factors

V Nold - 2022 - oparu.uni-ulm.de
… Even though the rise in glucocorticoids is rather unspecific, the Psycho-Immune-Neuro-Energy
(PINE) network responds with a variety of nuanced reactions that are modulated by …

Psychosocial interventions and immune system function: a systematic review and meta-analysis of randomized clinical trials

GS Shields, CM Spahr, GM Slavich - JAMA psychiatry, 2020 - jamanetwork.com
… and meta-analysis of randomized clinical trials (RCTs) in which we estimated associations
between 8 different psychosocial interventions and 7 markers of immune system function, and …

Prospective network analysis of proinflammatory proteins, lipid markers, and depression components in midlife community women

NH Zainal, MG Newman - Psychological medicine, 2023 - cambridge.org
… Our immune and endocrine systems dynamically interact with depressed mood and related
… IL-6), endocrine markers, and psychopathology components might have contributed to the …

[PDF][PDF] Consequences of Stress on the Psycho-Immune-Neuro-Energy Network

V Nold - 2021 - oparu.uni-ulm.de
… Even though the rise in glucocorticoids is rather unspecific, the Psycho-Immune-Neuro-Energy
(PINE) network responds with a variety of nuanced reactions that are modulated by …