… PTEN deletion is an established prognostic biomarker in prostate cancer. We compared
PTEN immunohistochemistry (IHC) and PTEN fluorescence in situ hybridization (FISH) in the …

… Accordingly, it is common for samples to show a positive FISH result and a negative/reduced
PTEN IHC, and much less common to have IHC positivity reported in cells carrying …

… analysis, PTEN gene loss showed an association with prostate cancer-… of PTEN status for
death from prostate cancer evaluated by IHC … treated prostate cancer with long-term follow-up. …

… % of cases where PTEN immunohistochemistry detected loss and PTEN FISH was initially …
the identical tumor core, rescreening the FISH guided by areas of immunohistochemistry loss …

… of recurrent prostate cancer. We previously showed by immunohistochemistry in paraffin-embedded
prostate tumor tissues obtained from patients with prostate cancer that increased …

… We found that loss of the PTEN tumor suppressor gene in prostate tumors as assessed
by tissue staining is correlated with shorter time to prostate cancer recurrence after radical …

… the assay of choice for use of PTEN as a biomarker. … PTEN expression as determined via
fluorescence IHC (FIHC) in primary tumor tissue is a more accurate biomarker for lethal prostate …

… c | Prostate tumour showing absence of PTEN expression by IHC with homozygous PTEN …
PTEN IHC image (top) shows loss of PTEN in tumour glands. Four-colour FISH image from an …

… To determine whether the PTEN IHC assay was sensitive or specific for … PTEN allelic loss
in clinical prostate cancer specimens, we evaluated PTEN protein by IHC in a series of prostate …

… Thus, we conclude that in the representative subset studied, PTEN immunohistochemistry
and PTEN FISH results were highly concordant. While 97% (65/67) of biopsies with intact …