… Emerging studies indicate that PTEN loss is … loss of PTEN are more likely to have an
immunosuppressive microenvironment, suggesting that advanced prostate cancers with PTEN loss …

… prostate cancer (log–rank, P = 0.003). No patient without PTEN loss developed metastases
or died from prostate … the use of PTEN loss as an early marker of aggressive prostate cancer. …

… , PTEN gene loss showed an association with prostate cancer-… value of PTEN status
for death from prostate cancer evaluated by … treated prostate cancer with long-term follow-up. …

… has driven the development of PTEN as a prognostic biomarker… factors and the consequences
of PTEN loss, in the context of … /PTEN/TOR signalling network in prostate cancer treatment. …

… Note intraductal spread of prostate cancer cells with PTEN loss within the larger … PTEN
loss in tumor sampled on a single TMA core with some cancer glands showing intact PTEN (…

… In this study, we investigated the level of PTEN loss by FISH in matched … PTEN loss does
not correlate with PTEN gene deletion, although all tumours with PTEN deletion have low PTEN …

… We created a PCa specific signature of the transcriptional landscape of PTEN loss that …
We also show that contrary to what is observed in other cancers, PTEN loss in PCa leads to …

… assess PTEN protein status in prostate cancer. Using this assay, we showed that PTEN protein
loss… with underlying genetic deletions of the PTEN gene and is associated with increased …

… cancer patients for treatments, which may improve … PTEN loss in the management of prostate
cancer and review recent therapeutic advances in targeting PTEN-deficient prostate cancer…

… varying from partial (1%–99% cancer cells) to complete loss (100% cancer cells) (5,7). The
… for PTEN as a biomarker. Because PTEN loss is strongly associated with prostate cancer …