… between PTEN FISH loss in CTCs and fresh tumour tissue … blood-based PTEN FISH assay
to determine PTEN gene status in … in PTEN status between archival and fresh prostate tumour …

… to PTEN loss in seven common tumour types and discuss mechanisms of PTEN regulation,
… an accumulation of oxidized PTEN and increased Akt signalling in oxidative tissues [101]. …

… detection of PTEN loss in tumour tissue and in blood liquid biopsies. The use of clinical-grade
assays in tumour tissue has shown a robust correlation between loss of PTEN and its …

… PTEN inactivation in tumours causes total loss of PTEN … PTEN loss leads to downstream
changes that govern important … the TME that are tumour-type specific or even tissue specific. …

… with characterized mutations, which give convincingly negative staining alongside
adjacent normal PTEN-expressing tissues. These data also identify large numbers of …

… loss of PTEN is found in 6% of HGSOC 11 and loss-of-function mutations of Pten allow for
accelerated tumour … We previously demonstrated that PTEN loss is prevalent in HGSOC using …

… deletion in mice leads to Cowden syndrome-like phenotypes, and tissue-specific Pten
deletion has provided clues to the role of PTEN mutation and loss in specific tumour types. …

… tumour suppressor gene activity in vitro and in vivo 4,5,6 . To explore the role of PTEN loss
in tumour maintenance, we developed shRNA transgenic mouse lines targeting Pten using …

… and nuclear PTEN expression was observed in prostate tissue. In the … , PTEN loss does
not correlate with PTEN gene deletion, although all tumours with PTEN deletion have low PTEN …

… To examine the role of PTEN in ontogenesis and tumour suppression, we disrupted mouse
Pten by … that the tumours identified in Pten chimaeras originated from tissues generated from …