… mutations in PTEN cause pleiotropic effects including cancer … associated with germline
PTEN mutation show highly variable … Indeed, the same mutation can cause either Cowden's …

… PS is characterized by overgrowth of tissue and bone, with no increased cancer risk. It has
been proposed that different PTEN mutations seen in the three syndromes could underlie …

… nuclear localization of mutant PTEN. Thus, our findings provide a molecular mechanism for
cancer-associated PTEN defects and may lead to a brain cancer treatment that targets PTEN …

… PTEN mutations, including identical PTEN mutations … PTEN mutations have been reported
in ∼60% of BRRS individuals (9, 13, 14). Among those without identified intragenic mutations…

… Here we report on a novel PTEN mutation that was found as a germline mutation in a … first
germline mutation reported for brain tumours of multiple lineages. The mutation changes an …

… presence of homozygous deletions of the PTEN gene; these were detected in 7 glioblastomas
that did not have PTEN mutations. Therefore, PTEN mutations occur in approximately 20…

… mutation; and in 2 of the cases, the p53 status is not known. None of the 5 GBMs with p53
mutations had PTEN mutations. … , 5 cases with p53 gene mutations, 1 case with both features, 4 …

… at the PTEN locus, and 60% (15 of 25) of these cases contained somatic PTEN mutations of
both alleles, implicating the PTEN gene in … The mutation rate of PTEN in this study could be …

… PTEN mutations are present in primary tumors, we screened genomic DNA from 18 primary
glioblastomas for mutations … cancers may harbor PTEN mutations, whereas the mutation …

… of the Pten protein in the normal development of the brain as … the involvement of aberrant
Pten function in the development … ) PTEN mutation cooperates with EGFR activation in human …