… In this Commentary, we focus on nuclear localization of PTEN, and the importance of this
in normal physiology and disease. Other non-traditional mechanisms of regulation are …

… It is generally thought that PTEN deficiencies … analysing PTEN in malignant glioblastoma
primary cells derived from 16 of our patients, we report mutations that block localization of PTEN …

… PTEN's cytoplasmic and nuclear localization and potential differential distribution of the protein
in healthy and diseased cells. In addition to cytoplasmic localization, PTEN was … PTEN in …

… To identify the potential stimuli that can modulate PTEN nuclear localization, we compared
… as a positive control for dominant PTEN nuclear localization as reported previously (Citation…

… We have demonstrated that somatic inactivation of PTEN is involved in both sporadic …
determine the relationship of PTEN mutation, 10q23 loss of heterozygosity, PTEN expression, and …

… Finally, nuclear localized P-AKT has been … point to nuclear PTEN potentially being required
for its tumor suppressor function. We have shown that PTEN has bipartite nuclear localization …

… Furthermore, catalytically active nuclear PTEN enhanced cell apoptotic responses. Our …
nuclear exclusion motifs and a nuclear localization domain control PTEN nuclear localization by …

… As we were carrying out the studies described in the first section of the Results, we also
sought PTEN mutants that showed decreased nuclear localization. Our approach was to mutate …

… PTEN nuclear localization have been proposed. These include the putative nuclear localization
signals within PTEN … responsible for Ran-mediated nuclear transport 11 and a potential …

… that phosphorylation of PTEN does not affect PTEN nuclear localization. Putative single
site nuclear localization sequence mutations in PTEN do not affect its nuclear-cytoplasmic …