… key genes encoding G10H, SCS and STR. This result indicated that many putative genes in
CPT synthesis … to be active tissues for CPT biosynthesis as well as accumulation. Expression …

… recently and applied in the nine step total synthesis of camptothecin [13]. Second, the …
for CPT biosynthesis, though the elucidation of enzymes involved in CPT biosynthesis has …

… alkaloid biosynthesis pathway and further determined other members of their gene families
(Supplementary Tables 16 and 17). We outlined the putative camptothecin biosynthetic …

… One putative SLS gene in C. acuminata was cloned (GenBank ID: HQ605982) by transcriptomic
sequencing and was likely targeted to the endoplasmic reticulum (ER) membrane by …

… putative pathway genes, transcription factors and CYPs related to camptothecin (CPT)
biosynthesis. … 10-hydroxylase) suggests its role in CPT biosynthesis. Tissue-specific LC-MS/MS …

… candidate orthologs for genes potentially involved in camptothecin biosynthesis. Extensive
… This resulted in 34 143 gene models assigned a putative function, 2011 annotated as …

… Putative biosynthetic pathway for MIAs. … Genome-wide identification and analysis of
AP2/ERF transcription factors related to camptothecin biosynthesis in Camptotheca acuminata. …

… camptothecin biosynthesis by light signals (Chang et al., 2019). In conclusion, the mining of
biosynthetic genes … are crucial for the camptothecin metabolic engineering in C. acuminata. …

… signature motifs of cytochrome P450 genes. Phylogenetic analysis of … P450 genes involved
in camptothecin biosynthesis in N. … as the putative cytochrome P450 genes involved in CPT …

… the biosynthesis of camptothecin (CPT) in Camptotheca acuminata. The primary and secondary
roles of CaSLSs-like genes in … Eight putative CaSLS-like homologs in the secologanin …