… representative EGFR inhibitors from the first generation to the third generation with EGFR
T790M kinase (Fig. … The first generation of EGFR-TKIs are mainly 4-phenylaminoquinazoline …

… ) depends on several pyrimidine derivatives including adenine, guanine, … EGFR inhibitors
as anticancer agents (Al-Anazi et al., 2018; Al-Anazi et al., 2021), compounds with pyrimidine …

… EGFR and HER2 inhibitors which contain pyrimidine ring. The compilation of data from
sub-class of pyrimidine derivatives … in designing of EGFR and HER2 inhibitors. The summary of …

… We designed and synthesized five series of thiophene-pyrimidine derivatives in this paper.
The most promising compound showed superior activity against A549, A431 and Hela, with …

… 2,3-d]pyrimidine derivatives as an EGFR and HER2 tyrosine kinase inhibitors. All the
synthesized compounds were evaluated in vitro for their inhibitory activities against EGFR WT ; and …

… Docking studies into ATP binding site of EGFR protein tyrosine kinase were performed to …
(EGFR-TK) was evaluated. Results indicated the ability of the target compounds to inhibit EGFR…

… types, EGFR (… ]pyrimidine derivatives was designed, synthesized and biologically evaluated.
Modification of the solvent accessible 5-position side chain greatly affected the in-vitro EGFR…

… to develop effective EGFR-TKIs, two series of 1H-pyrazolo[3,4-d]pyrimidine derivatives were
… inhibitory activities against EGFR WT . Compounds 15 b , 15 j , and 18 d potently inhibited …

… especially pyrimidine containing … inhibitors of EGFR tyrosine kinase (TK) domain [17].
Clinical data have shown the significant influence of pyrimidine derivatives as EGFR TK inhibitors …

… Our group also reported that 8-phenylthio-9H-purine, 28 9-heterocyclyl substituted 9H-purines
29 and pyrido[3,4-d]pyrimidine derivatives 30 as new EGFR L858R/T790M/C797S …