… how pyrimidine metabolism … of pyrimidine metabolism during nonpathogenic cellular events.
We then focus on changes that pathogen infections cause in the pyrimidine metabolism of …

… cell/organism perspective? This review will focus on recent studies on purine and pyrimidine
metabolism, … In TK2 deficient mice, mtDNA depletion leads to abnormal development of …

… enzyme involved in purine and pyrimidine metabolism, is the rate-… development of neoplasia
are genetic events that turn proto-oncogenes, encoding proteins that act as agonists of cell …

… In this direction, our laboratory has demonstrated that exposing NSCLC cell lines to
increasing doses of 5-FU up-regulated the expression of its target, TS. The cells developed …

… deaminase, and pyrimidine cleavage activities have been detected in cell-free homogenates;
no uridine kinase activity was detected (94). In summary, pyrimidine metabolism in the …

… leading to developmental delay are detected by analysis of the urine for pyrimidines and …
whom levels of enzyme activity in the whole cell assay were intermediate. These neurologic …

… conceptual advances on pyrimidine metabolism, especially … development of new drug
precisely targeting the pyrimidine … pyrimidine metabolism in AML, we then analyzed the cellular …

Benzylacyclouridines were developed as specific and potent competitive inhibitors ofuridine
phosphorylase with K, values in the nanomolar range. These compounds have no activity …

… on those involved in purine and pyrimidine metabolism. These structures have important …
cellular processes and as fertile ground for new targets for drug discovery and development…

… development and function of several organs, in particular central nervous system. Alterations
of purine and pyrimidine metabolism … specialized cell types with specific metabolic pathways…